Preventive use of diltiazem to suppress supraventricular tachyarrhythmia in the patients after esophagectomy

Muneaki Shimada, Harumi Namai, Hiroshi Morisaki, Ryoichi Ochiai, Junzo Takeda, Kazuaki Fukushima

研究成果: Article

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We investigated the efficacy of preventive use of diltiazem to suppress supraventricular tachyarrhythmia such as paroxysmal atrial tachycardia (PAT) and atrial fibrillation (Af) in the patients who underwent transthoracic esophagectomy. We divided 52 patients into 2 groups; the diltiazem group (n=26) and the control group (n=26). In the diltiazem group continuous intravenous infusion of diltiazem (1-3mcg · kg-1 · min-1) was started when the patient's heart rate remained over 110 · min-1 without any predisposing factor. On the other hand, in the control group we did not use it preventively. In both groups, we did not restrict the use of antiarrhythmic agents if necessary. We recognized PAT or Af in the control group (54 %) more often than in the diltiazem group (19 %). PAT or Af seldom occurred after the 4th post-operative day in the both groups. Serum diltiazem concentrations of 9 patients after about 10 hours infusion showed great variation (between 30 and 250 ng · ml-1). In 7 of them the diltiazem concentration increased as the duration of infusion was prolonged. However, we did not observe bradyarrhythmia. We consider that the continuous diltiazem infusion is effective in suppressing supraventricular tachyarrhythmia after esophagectomy.

元の言語English
ページ(範囲)658-663
ページ数6
ジャーナルJapanese Journal of Anesthesiology
46
発行部数5
出版物ステータスPublished - 1997 5 1

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

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