Primary malignant hepatic pheochromocytoma with negative adrenal scintigraphy

Koichiro Homma, Koichi Hayashi, Shu Wakino, Rie Irie, Makio Mukai, Hiroo Kumagai, Hirotaka Shibata, Takao Saruta

研究成果: Article査読

6 被引用数 (Scopus)


A 60-year-old male patient with hypertension was referred to our hospital because of insufficient blood pressure control (190/98 mmHg) and to rule out secondary hypertension. A computed tomography scan revealed no adrenal tumor but a large liver mass (5 × 5 cm), and magnetic resonance imaging showed a high signal intensity lesion on the T2-weighted image. Twenty-four hour urinary excretion of catecholamine metabolites was markedly increased, although a 123l-metaiodobenzyl guanidine (MIBG) scintigram failed to show accumulation in the hepatic mass, and no difference was noted between the catecholamine concentration in the tumor-drainage vein and that obtained from the vein draining from the non-tumor area. Liver biopsy did show features compatible with pheochromocytoma (i.e., chromogranin A-positive cells). Transcatheter arterial embolization of the liver tumor was conducted and resulted in a marked (50%) decrease in the 24-h urine normetanephrine excretion. Several metastatic foci were noted in the spinal bone and transcatheter arterial embolization (TAE) was also conducted with successful results. Thus, we experienced a case of primary malignant hepatic pheochromocytoma with negative 123l-MIBG scanning.

ジャーナルHypertension Research
出版ステータスPublished - 2006 7

ASJC Scopus subject areas

  • 内科学
  • 生理学
  • 循環器および心血管医学


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