Primary natural killer cell lymphoma of the lacrimal sac

Takehiko Mori, M. Tokuhira, S. Mori, N. Sato, I. Miura, A. Adachi, H. Kuroda, J. Tamaru, S. Itoyama, H. Suzuki, T. Abe, Tsutomu Takeuchi

研究成果: Article

18 引用 (Scopus)

抄録

Primary lymphoid tumors of the lacrimal sac are quite rare, and all reported cases are of B-cell tumors with good prognosis. To our knowledge, this is the first case of primary natural killer (NK) cell lymphoma of the lacrimal sac. A 55-year-old woman presented with a lacrimal sac tumor, and histological diagnosis of NK cell lymphoma was made. Although disease was initially localized to the right lacrimal sac, it invaded into the adjacent ethmoidal sinus before chemotherapy was initiated (clinical stage IIE). Epstein-Barr virus (EBV)-encoded small RNA (EBER) was detected in lymphoma cells by in situ hybridization. Systemic chemotherapy combined with intrathecal chemotherapy followed by local radiotherapy was performed, and the patient achieved complete remission. However, shortly after completion of chemoradiotherapy, the lymphoma relapsed with rapid systemic dissemination. The disease was refractory to chemotherapy, and the patient eventually succumbed due to sepsis.

元の言語English
ページ(範囲)607-610
ページ数4
ジャーナルAnnals of Hematology
80
発行部数10
DOI
出版物ステータスPublished - 2001

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Nasolacrimal Duct
Natural Killer Cells
Lymphoma
Drug Therapy
Neoplasms
Chemoradiotherapy
Human Herpesvirus 4
In Situ Hybridization
Sepsis
B-Lymphocytes
Radiotherapy
RNA

ASJC Scopus subject areas

  • Hematology

これを引用

Primary natural killer cell lymphoma of the lacrimal sac. / Mori, Takehiko; Tokuhira, M.; Mori, S.; Sato, N.; Miura, I.; Adachi, A.; Kuroda, H.; Tamaru, J.; Itoyama, S.; Suzuki, H.; Abe, T.; Takeuchi, Tsutomu.

:: Annals of Hematology, 巻 80, 番号 10, 2001, p. 607-610.

研究成果: Article

Mori, T, Tokuhira, M, Mori, S, Sato, N, Miura, I, Adachi, A, Kuroda, H, Tamaru, J, Itoyama, S, Suzuki, H, Abe, T & Takeuchi, T 2001, 'Primary natural killer cell lymphoma of the lacrimal sac', Annals of Hematology, 巻. 80, 番号 10, pp. 607-610. https://doi.org/10.1007/s002770100368
Mori T, Tokuhira M, Mori S, Sato N, Miura I, Adachi A その他. Primary natural killer cell lymphoma of the lacrimal sac. Annals of Hematology. 2001;80(10):607-610. https://doi.org/10.1007/s002770100368
Mori, Takehiko ; Tokuhira, M. ; Mori, S. ; Sato, N. ; Miura, I. ; Adachi, A. ; Kuroda, H. ; Tamaru, J. ; Itoyama, S. ; Suzuki, H. ; Abe, T. ; Takeuchi, Tsutomu. / Primary natural killer cell lymphoma of the lacrimal sac. :: Annals of Hematology. 2001 ; 巻 80, 番号 10. pp. 607-610.
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AU - Mori, Takehiko

AU - Tokuhira, M.

AU - Mori, S.

AU - Sato, N.

AU - Miura, I.

AU - Adachi, A.

AU - Kuroda, H.

AU - Tamaru, J.

AU - Itoyama, S.

AU - Suzuki, H.

AU - Abe, T.

AU - Takeuchi, Tsutomu

PY - 2001

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N2 - Primary lymphoid tumors of the lacrimal sac are quite rare, and all reported cases are of B-cell tumors with good prognosis. To our knowledge, this is the first case of primary natural killer (NK) cell lymphoma of the lacrimal sac. A 55-year-old woman presented with a lacrimal sac tumor, and histological diagnosis of NK cell lymphoma was made. Although disease was initially localized to the right lacrimal sac, it invaded into the adjacent ethmoidal sinus before chemotherapy was initiated (clinical stage IIE). Epstein-Barr virus (EBV)-encoded small RNA (EBER) was detected in lymphoma cells by in situ hybridization. Systemic chemotherapy combined with intrathecal chemotherapy followed by local radiotherapy was performed, and the patient achieved complete remission. However, shortly after completion of chemoradiotherapy, the lymphoma relapsed with rapid systemic dissemination. The disease was refractory to chemotherapy, and the patient eventually succumbed due to sepsis.

AB - Primary lymphoid tumors of the lacrimal sac are quite rare, and all reported cases are of B-cell tumors with good prognosis. To our knowledge, this is the first case of primary natural killer (NK) cell lymphoma of the lacrimal sac. A 55-year-old woman presented with a lacrimal sac tumor, and histological diagnosis of NK cell lymphoma was made. Although disease was initially localized to the right lacrimal sac, it invaded into the adjacent ethmoidal sinus before chemotherapy was initiated (clinical stage IIE). Epstein-Barr virus (EBV)-encoded small RNA (EBER) was detected in lymphoma cells by in situ hybridization. Systemic chemotherapy combined with intrathecal chemotherapy followed by local radiotherapy was performed, and the patient achieved complete remission. However, shortly after completion of chemoradiotherapy, the lymphoma relapsed with rapid systemic dissemination. The disease was refractory to chemotherapy, and the patient eventually succumbed due to sepsis.

KW - EBER

KW - Epstein-Barr virus

KW - Lacrimal sac

KW - Natural killer (NK) cell

KW - Natural killer (NK) cell lymphoma

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