Priming of alveolar macrophages for interleukin-8 production in patients with idiopathic pulmonary fibrosis

Hidetoshi Nakamura, Seitaro Fujishima, Yasuhiro Waki, Tetsuya Urano, Koichi Sayama, Fumio Sakamaki, Takeshi Terashima, Kenzo Soejima, Sadatomo Tasaka, Akitoshi Ishizaka, Takeo Kawashiro, Minoru Kanazawa

研究成果: Article査読

43 被引用数 (Scopus)

抄録

We evaluated the contribution of interleukin-8 (IL-8) to the pathogenesis of idiopathic pulmonary fibrosis (IPF) by studying bronchoalveolar lavage fluid (BALF) in eight patients with IPF in the chronically progressive phase, five patients with IPF in the subacutely progressive phase, eight patients with sarcoidosis (SAR), and eight control (CTL) subjects. IL-8 levels were not increased in the BALF of the patients with IPF in the chronic phase (11.3 ± 8.8 pg/ml), nor in that of the SAR patients (13.8 ± 7.8 pg/ml), whereas they were increased in the BALF of patients with IPF in the subacutely progressive phase (1.93 ± 1.10 ng/ml). We then investigated extracellular and cell-associated IL-8 in lipopolysaccharide (LPS)-stimulated BALF cells to determine the IL-8-producing potential of alveolar macrophages (AM). Following LPS stimulation of BALF cells from patients with IPF in the chronic phase, both the extracellular IL-8 in culture fluid and the cell-associated IL-8 in AM were increased as compared with those for the CTL subjects (p< 0.05 and p< 0.05, respectively). These results suggest that AM of patients with IPF are primed for IL-8 production. We conclude that IL-8 may play a role in neutrophilic alveolitis, especially during the subacute phase of IPF.

本文言語English
ページ(範囲)1579-1586
ページ数8
ジャーナルAmerican journal of respiratory and critical care medicine
152
5 I
DOI
出版ステータスPublished - 1995 11月

ASJC Scopus subject areas

  • 呼吸器内科
  • 集中医療医学

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