Prognostic impact of subsequent acute coronary syndrome and unplanned revascularization on long-term mortality after an index percutaneous coronary intervention: A report from a Japanese multicenter registry

Taku Inohara, Shun Kohsaka, Hiroaki Miyata, Mitsuaki Sawano, Ikuko Ueda, Yuichiro Maekawa, Keiichi Fukuda, Philip G. Jones, David J. Cohen, Zhenxiang Zhao, John A. Spertus, Kim G. Smolderen

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Background--Whereas composite end points are often used in clinical trials of percutaneous coronary interventions (PCI), the impact of individual components on subsequent survival is incompletely defined. We evaluated the association of subsequent acute coronary syndromes (ACS) and unplanned coronary revascularization post-PCI with long-term survival. Methods and Results--From 2009 to 2011, the KiCS-PCI (Keio interhospital Cardiovascular Studies) consecutively enrolled patients undergoing PCI in14 Japanese teaching hospitals.Weidentified patientswhoexperiencedACSor unplanned coronary revascularization following their index PCI and compared subsequent survival during the 2-year follow-up period using propensity-matched cohorts of patients who did and did not experience these events. Cox proportional hazard models were used to assess 2-year all-cause mortality. Because unstable anginais less severe than acutemyocardial infarction,wealsogeneratedaseparate propensity-matchedcohort forUA post-PCI. Among 3348 PCI patients (mean age, 67.5±10.7 years; 79.7% male), 214 (6.4%) experienced a subsequent ACS (168 events [78.5%]wereunstable angina),and198(5.9%)underwent unplannedrevascularization. In the propensity-matchedcohorts, patients with a subsequent ACS admission had an increased risk of mortality as compared with those without (hazard ratio, 4.73; 95% confidence interval=1.35-16.6; P=0.015), whereas those with an unplanned revascularization did not have significantly higher risk (hazard ratio, 2.97; 95% confidence interval=0.57-14.3; P=0.19).Among unstable angina events, no association with mortality was observed (hazard ratio, 1.39; 95% confidence interval=0.48-4.00; P=0.54). Conclusions--In the KiCS-PCI registry, the incidence of a subsequent ACS was associated with higher mortality, but this association was less apparent after unplanned coronary revascularization or unstable angina. The prognostic implications of different outcomes in a composite end point should be considered when interpreting the results of clinical trials in PCI.

元の言語English
記事番号e006529
ジャーナルJournal of the American Heart Association
6
発行部数11
DOI
出版物ステータスPublished - 2017 11 1

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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