Prognostic significance of [18F]fluorodeoxyglucose uptake on positron emission tomography in patients with pathologic stage I lung adenocarcinoma

Takashi Ohtsuka, Hiroaki Nomori, Ken Ichi Watanabe, Masahiro Kaji, Tsuguo Maruke, Keiichi Suemasu, Kimiichi Uno

研究成果: Article

91 引用 (Scopus)

抄録

BACKGROUND. [18F]Fluoro-2-deoxyglucose uptake on positron emission tomography (FDG-PET) has been frequently used for diagnosis and staging of lung cancer. The prognostic significance of FDG uptake on PET was evaluated in patients with pathologic Stage I lung adenocarcinoma (tumor stages were based on the TNM classification of the International Union Against Cancer). METHODS. Disease-free survival of 98 patients with pathologic Stage I lung adenocarcinoma who were treated by curative resection was examined in relation to sex, age, histologic grade of differentiation, surgical procedure, tumor stage, and FDG uptake measured as the maximum standardized uptake value (SUV). RESULTS. Sixty-three patients were had Stage IA disease and 35 patients had Stage IB disease. Six patients each with Stage IA and Stage IB disease developed disease recurrence after a mean postsurgical follow-up period of 31 months. Ten (23%) of the 43 patients with SUV ≥ 3.3 developed a recurrence compared with 2 (4%) of the 55 patients with SUV < 3.3 (P = .020). Ten (20%) of the 51 patients with moderately or poorly differentiated adenocarcinoma developed disease recurrence, compared with 2 (4%) of the 47 patients with well-differentiated adenocarcinoma (P = .056). Multivariate analysis demonstrated that histologic grade of differentiation was not correlated with the frequency of tumor recurrence (P = .286), whereas SUV was found to be marginally correlated (P = .079). CONCLUSIONS. FDG uptake appears to be predictive of disease-free survival in patients with Stage I lung adenocarcinoma. FDG uptake could yield important information for determining the likely value of postoperative adjuvant chemotherapy in such patients.

元の言語English
ページ(範囲)2468-2473
ページ数6
ジャーナルCancer
107
発行部数10
DOI
出版物ステータスPublished - 2006 11 15
外部発表Yes

Fingerprint

Fluorodeoxyglucose F18
Positron-Emission Tomography
Recurrence
Disease-Free Survival
Adenocarcinoma
Adenocarcinoma of lung
Neoplasms
Neoplasm Staging
Deoxyglucose
Adjuvant Chemotherapy
Lung Neoplasms
Multivariate Analysis

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

これを引用

Prognostic significance of [18F]fluorodeoxyglucose uptake on positron emission tomography in patients with pathologic stage I lung adenocarcinoma. / Ohtsuka, Takashi; Nomori, Hiroaki; Watanabe, Ken Ichi; Kaji, Masahiro; Maruke, Tsuguo; Suemasu, Keiichi; Uno, Kimiichi.

:: Cancer, 巻 107, 番号 10, 15.11.2006, p. 2468-2473.

研究成果: Article

Ohtsuka, T, Nomori, H, Watanabe, KI, Kaji, M, Maruke, T, Suemasu, K & Uno, K 2006, 'Prognostic significance of [18F]fluorodeoxyglucose uptake on positron emission tomography in patients with pathologic stage I lung adenocarcinoma', Cancer, 巻. 107, 番号 10, pp. 2468-2473. https://doi.org/10.1002/cncr.22268
Ohtsuka, Takashi ; Nomori, Hiroaki ; Watanabe, Ken Ichi ; Kaji, Masahiro ; Maruke, Tsuguo ; Suemasu, Keiichi ; Uno, Kimiichi. / Prognostic significance of [18F]fluorodeoxyglucose uptake on positron emission tomography in patients with pathologic stage I lung adenocarcinoma. :: Cancer. 2006 ; 巻 107, 番号 10. pp. 2468-2473.
@article{7d57f1fda6a648b6aa4befabd60482a9,
title = "Prognostic significance of [18F]fluorodeoxyglucose uptake on positron emission tomography in patients with pathologic stage I lung adenocarcinoma",
abstract = "BACKGROUND. [18F]Fluoro-2-deoxyglucose uptake on positron emission tomography (FDG-PET) has been frequently used for diagnosis and staging of lung cancer. The prognostic significance of FDG uptake on PET was evaluated in patients with pathologic Stage I lung adenocarcinoma (tumor stages were based on the TNM classification of the International Union Against Cancer). METHODS. Disease-free survival of 98 patients with pathologic Stage I lung adenocarcinoma who were treated by curative resection was examined in relation to sex, age, histologic grade of differentiation, surgical procedure, tumor stage, and FDG uptake measured as the maximum standardized uptake value (SUV). RESULTS. Sixty-three patients were had Stage IA disease and 35 patients had Stage IB disease. Six patients each with Stage IA and Stage IB disease developed disease recurrence after a mean postsurgical follow-up period of 31 months. Ten (23{\%}) of the 43 patients with SUV ≥ 3.3 developed a recurrence compared with 2 (4{\%}) of the 55 patients with SUV < 3.3 (P = .020). Ten (20{\%}) of the 51 patients with moderately or poorly differentiated adenocarcinoma developed disease recurrence, compared with 2 (4{\%}) of the 47 patients with well-differentiated adenocarcinoma (P = .056). Multivariate analysis demonstrated that histologic grade of differentiation was not correlated with the frequency of tumor recurrence (P = .286), whereas SUV was found to be marginally correlated (P = .079). CONCLUSIONS. FDG uptake appears to be predictive of disease-free survival in patients with Stage I lung adenocarcinoma. FDG uptake could yield important information for determining the likely value of postoperative adjuvant chemotherapy in such patients.",
keywords = "Lung cancer, Positron emission tomography, Prognosis, Recurrence",
author = "Takashi Ohtsuka and Hiroaki Nomori and Watanabe, {Ken Ichi} and Masahiro Kaji and Tsuguo Maruke and Keiichi Suemasu and Kimiichi Uno",
year = "2006",
month = "11",
day = "15",
doi = "10.1002/cncr.22268",
language = "English",
volume = "107",
pages = "2468--2473",
journal = "Cancer",
issn = "0008-543X",
publisher = "John Wiley and Sons Inc.",
number = "10",

}

TY - JOUR

T1 - Prognostic significance of [18F]fluorodeoxyglucose uptake on positron emission tomography in patients with pathologic stage I lung adenocarcinoma

AU - Ohtsuka, Takashi

AU - Nomori, Hiroaki

AU - Watanabe, Ken Ichi

AU - Kaji, Masahiro

AU - Maruke, Tsuguo

AU - Suemasu, Keiichi

AU - Uno, Kimiichi

PY - 2006/11/15

Y1 - 2006/11/15

N2 - BACKGROUND. [18F]Fluoro-2-deoxyglucose uptake on positron emission tomography (FDG-PET) has been frequently used for diagnosis and staging of lung cancer. The prognostic significance of FDG uptake on PET was evaluated in patients with pathologic Stage I lung adenocarcinoma (tumor stages were based on the TNM classification of the International Union Against Cancer). METHODS. Disease-free survival of 98 patients with pathologic Stage I lung adenocarcinoma who were treated by curative resection was examined in relation to sex, age, histologic grade of differentiation, surgical procedure, tumor stage, and FDG uptake measured as the maximum standardized uptake value (SUV). RESULTS. Sixty-three patients were had Stage IA disease and 35 patients had Stage IB disease. Six patients each with Stage IA and Stage IB disease developed disease recurrence after a mean postsurgical follow-up period of 31 months. Ten (23%) of the 43 patients with SUV ≥ 3.3 developed a recurrence compared with 2 (4%) of the 55 patients with SUV < 3.3 (P = .020). Ten (20%) of the 51 patients with moderately or poorly differentiated adenocarcinoma developed disease recurrence, compared with 2 (4%) of the 47 patients with well-differentiated adenocarcinoma (P = .056). Multivariate analysis demonstrated that histologic grade of differentiation was not correlated with the frequency of tumor recurrence (P = .286), whereas SUV was found to be marginally correlated (P = .079). CONCLUSIONS. FDG uptake appears to be predictive of disease-free survival in patients with Stage I lung adenocarcinoma. FDG uptake could yield important information for determining the likely value of postoperative adjuvant chemotherapy in such patients.

AB - BACKGROUND. [18F]Fluoro-2-deoxyglucose uptake on positron emission tomography (FDG-PET) has been frequently used for diagnosis and staging of lung cancer. The prognostic significance of FDG uptake on PET was evaluated in patients with pathologic Stage I lung adenocarcinoma (tumor stages were based on the TNM classification of the International Union Against Cancer). METHODS. Disease-free survival of 98 patients with pathologic Stage I lung adenocarcinoma who were treated by curative resection was examined in relation to sex, age, histologic grade of differentiation, surgical procedure, tumor stage, and FDG uptake measured as the maximum standardized uptake value (SUV). RESULTS. Sixty-three patients were had Stage IA disease and 35 patients had Stage IB disease. Six patients each with Stage IA and Stage IB disease developed disease recurrence after a mean postsurgical follow-up period of 31 months. Ten (23%) of the 43 patients with SUV ≥ 3.3 developed a recurrence compared with 2 (4%) of the 55 patients with SUV < 3.3 (P = .020). Ten (20%) of the 51 patients with moderately or poorly differentiated adenocarcinoma developed disease recurrence, compared with 2 (4%) of the 47 patients with well-differentiated adenocarcinoma (P = .056). Multivariate analysis demonstrated that histologic grade of differentiation was not correlated with the frequency of tumor recurrence (P = .286), whereas SUV was found to be marginally correlated (P = .079). CONCLUSIONS. FDG uptake appears to be predictive of disease-free survival in patients with Stage I lung adenocarcinoma. FDG uptake could yield important information for determining the likely value of postoperative adjuvant chemotherapy in such patients.

KW - Lung cancer

KW - Positron emission tomography

KW - Prognosis

KW - Recurrence

UR - http://www.scopus.com/inward/record.url?scp=33750975903&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33750975903&partnerID=8YFLogxK

U2 - 10.1002/cncr.22268

DO - 10.1002/cncr.22268

M3 - Article

C2 - 17036361

AN - SCOPUS:33750975903

VL - 107

SP - 2468

EP - 2473

JO - Cancer

JF - Cancer

SN - 0008-543X

IS - 10

ER -