Prognostic significance of tissue factor in pancreatic ductal adenocarcinoma

Nobuhiro Nitori, Yoshinori Ino, Yukihiro Nakanishi, Tesshi Yamada, Kazufumi Honda, Kazuyoshi Yanagihara, Tomoo Kosuge, Yae Kanai, Masaki Kitajima, Setsuo Hirohashi, Tsuo Tirchashi

研究成果: Article

115 引用 (Scopus)

抜粋

Tissue factor (TF) is a transmembrane glycoprotein that plays roles in the blood coagulation and intracellular signaling pathways, and has also been suggested to modulate the biological behavior of cancer cells. In order to examine the clinicopathologic significance of TF expression in pancreatic ductal adenocarcinoma, TF expression was determined by immunohistochemistry using a newly raised anti-TF monoclonal antibody in 113 patients who had undergone surgical resection of pancreatic ductal adenocarcinoma. According to the incidence of tumor cell immunopositivity, patients were divided into "negative TF" (0%), "weak TF" (<25%), or "high TF" (25% or more) groups, which accounted for 11.6% (n = 13), 44.2% (n = 50), and 44.2% (n = 50) of the total, respectively. Increased TF expression was correlated with the extent of the primary tumor (P = 0.0043), lymph node metastasis (P = 0.0043), lymphatic distant metastasis (P = 0.0039), advanced tumor-node-metastasis stage (P = 0.0002), and high tumor grade (P = 0.0164). Multivariate analysis using the Cox proportional hazards model showed that high TF expression was an independent negative predictor for survival (hazard ratio, 2.014; P = 0.0076). Moreover, patients with TF-negative tumors had a significantly better prognosis even if lymph node metastasis was present (P < 0.0001). We also showed that TF knockdown by RNA interference suppressed the invasiveness of a pancreatic adenocarcinoma cell line in vitro. These results indicate that TF expression may contribute to the aggressiveness of pancreatic ductal adenocarcinoma by stimulating tumor invasiveness, and that evaluation of the primary tumor for TF expression may identify patients with a poor prognosis.

元の言語English
ページ(範囲)2531-2539
ページ数9
ジャーナルClinical Cancer Research
11
発行部数7
DOI
出版物ステータスPublished - 2005 4 1
外部発表Yes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

フィンガープリント Prognostic significance of tissue factor in pancreatic ductal adenocarcinoma' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

  • これを引用

    Nitori, N., Ino, Y., Nakanishi, Y., Yamada, T., Honda, K., Yanagihara, K., Kosuge, T., Kanai, Y., Kitajima, M., Hirohashi, S., & Tirchashi, T. (2005). Prognostic significance of tissue factor in pancreatic ductal adenocarcinoma. Clinical Cancer Research, 11(7), 2531-2539. https://doi.org/10.1158/1078-0432.CCR-04-0866