Prognostic value of intraoperative pleural lavage cytology for non-small cell lung cancer: The influence of positive pleural lavage cytology results on T classification

Kotaro Kameyama, Norihito Okumura, Etsuo Miyaoka, Hisao Asamura, Ichiro Yoshino, Hirohito Tada, Yoshitaka Fujii, Yoichi Nakanishi, Kenji Eguchi, Masaki Mori, Hideo Kobayashi, Noriyoshi Sawabata, Meinoshin Okumura, Kohei Yokoi

研究成果: Article査読

16 被引用数 (Scopus)

抄録

Results A total of 217 patients (5.2%) were PLC-positive, which was significantly associated with a higher incidence of adenocarcinoma and advanced disease. The 5-year survival for patients with positive and negative PLC results were 44.5% and 72.8%, respectively, and this difference in survival was statistically significant (P <.001). Multivariate analysis showed that positive PLC status was an independent factor for a poor prognosis (hazard ratio, 1.57; P <.001). Significant differences in survival were also found between patients with positive and negative PLC results in the same T categories and stages, including T2a, T3, stage IB, and stage IIIA. The IPLCC recommendations adjusted the prognostic differences in all T categories and stages. The significant difference in survival disappeared between the 2 groups in all T categories and stages.

Conclusions Our results indicate that a T category upgrade is prognostically adequate for patients who are PLC-positive.

Objective Although positive pleural lavage cytology (PLC) has been demonstrated to be closely associated with a poor prognosis for patients with lung cancer, it has not been incorporated into the TNM staging system of the Union for International Cancer Control. The aim of our study was to retrospectively examine the clinical significance of PLC status and illustrate the recommendations of the International Pleural Lavage Cytology Collaborators (IPLCC) in a large national database.

本文言語English
ページ(範囲)2659-2664
ページ数6
ジャーナルJournal of Thoracic and Cardiovascular Surgery
148
6
DOI
出版ステータスPublished - 2014 12月 1
外部発表はい

ASJC Scopus subject areas

  • 外科
  • 呼吸器内科
  • 循環器および心血管医学

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