Prognostic values of clockwise and counterclockwise rotation for cardiovascular mortality in Japanese subjects: A 24-year follow-up of the National Integrated Project for Prospective Observation of Noncommunicable Disease and its Trends in the Aged, 1980-2004 (NIPPON DATA80)

Yasuyuki Nakamura, Tomonori Okamura, Aya Higashiyama, Makoto Watanabe, Aya Kadota, Takayoshi Ohkubo, Katsuyuki Miura, Fumiyoshi Kasagi, Kazunori Kodama, Akira Okayama, Hirotsugu Ueshima

研究成果: Article査読

18 被引用数 (Scopus)

抄録

Background: Although clockwise rotation and counterclockwise rotation are distinct findings of the ECG, their prognostic significance is rarely studied. Methods and Results: We studied prognostic values of clockwise and counterclockwise rotation on total, cardiovascular disease (CVD), and subtype mortality using the National Integrated Project for Prospective Observation of Noncommunicable Disease and Its Trends in the Aged, 1980-2004 (NIPPON DATA80) database with a 24-year follow-up. At baseline in 1980, data were collected on study participants aged ≥30 years from randomly selected areas in Japan. We followed 9067 participants (44% men; mean age, 51 years). During the 24-year follow-up, mortality was as follows: 2581 total, 887 CVD, 179 coronary heart disease, 173 heart failure, and 411 stroke. The multivariate-adjusted hazard ratio (HR) with the use of the Cox model including biochemical and other ECG variables revealed that clockwise rotation was significantly positively associated with heart failure in men and women combined (HR=1.79; 95% confidence interval [CI], 1.13-2.83; P=0.013), CVD in men and in men and women combined (HR=1.49; 95% CI, 1.12-1.98; P=0.007 in men; HR=1.28; 95% CI, 1.02-1.59; P=0.030 in combined), and total mortality in men and in men and women combined (HR=1.19; 95% CI, 1.00-1.49; P=0.0496inmen; HR=1.15; 95% CI, 1.00-1.32; P=0.045 in combined). Counterclockwise rotation was significantly inversely associated stroke in men and women combined (HR=0.77; 95% CI, 0.62-0.96; P=0.017), CVD in men and in men and women combined (HR=0.74; 95% CI, 0.59-0.94; P=0.011 in men; HR=0.81; 95% CI, 0.70-0.94; P=0.006 in combined), and total mortality in women (HR=0.87; 95% CI, 0.77-0.98; P=0.023). Conclusions: We found a significant positive association of clockwise rotation and a significant inverse association of counterclockwise rotation with CVD mortality in men and in men and women combined, independent of confounding factors including other ECG changes.

本文言語English
ページ(範囲)1226-1233
ページ数8
ジャーナルCirculation
125
10
DOI
出版ステータスPublished - 2012 3 13

ASJC Scopus subject areas

  • 循環器および心血管医学
  • 生理学(医学)

フィンガープリント

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