Proliferation of neuroblasts in the adult brain: Role of diversin

Yuki Hirota, Kazunobu Sawamoto

研究成果: Chapter

抄録

The subventricular zone (SVZ) is the largest neurogenic region in the adult rodent brain. In this region, new neurons that originate from neural stem cells (NSCs) migrate to the olfactory bulb, where they mature into interneurons. During neurogenesis, the proliferation of NSCs and neuronal progenitor cells are precisely regulated by multiple signaling pathways to maintain homeostasis. Wnt signaling is one mechanism that controls the proliferation of SVZ cells. In addition to NSCs and progenitor cells, the migration of new neurons (neuroblasts) also maintains the proliferative capacity. Recently, Diversin, which is a component of the Wnt signaling pathway, has been shown to promote the proliferation of neuroblasts in the SVZ. Neuroblast proliferation may be an important step in regenerative responses to brain injury and in normal physio–logical neurogenesis.

元の言語English
ホスト出版物のタイトルTumors of the Central Nervous System, Volume 9
ホスト出版物のサブタイトルLymphoma, Supratentorial Tumors, Glioneuronal Tumors, Gangliogliomas, Neuroblastoma in Adults, Astrocytomas, Ependymomas, Hemangiomas, and Craniopharyngiomas
出版者Springer Netherlands
ページ177-183
ページ数7
ISBN(電子版)9789400754881
ISBN(印刷物)9789400754874
DOI
出版物ステータスPublished - 2012 1 1
外部発表Yes

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Neural Stem Cells
Lateral Ventricles
Neurogenesis
Brain
Stem Cells
Neurons
Wnt Signaling Pathway
Olfactory Bulb
Interneurons
Brain Injuries
Cell Movement
Rodentia
Homeostasis
diversin

ASJC Scopus subject areas

  • Medicine(all)

これを引用

Hirota, Y., & Sawamoto, K. (2012). Proliferation of neuroblasts in the adult brain: Role of diversin. : Tumors of the Central Nervous System, Volume 9: Lymphoma, Supratentorial Tumors, Glioneuronal Tumors, Gangliogliomas, Neuroblastoma in Adults, Astrocytomas, Ependymomas, Hemangiomas, and Craniopharyngiomas (pp. 177-183). Springer Netherlands. https://doi.org/10.1007/978-94-007-5488-1_20

Proliferation of neuroblasts in the adult brain : Role of diversin. / Hirota, Yuki; Sawamoto, Kazunobu.

Tumors of the Central Nervous System, Volume 9: Lymphoma, Supratentorial Tumors, Glioneuronal Tumors, Gangliogliomas, Neuroblastoma in Adults, Astrocytomas, Ependymomas, Hemangiomas, and Craniopharyngiomas. Springer Netherlands, 2012. p. 177-183.

研究成果: Chapter

Hirota, Y & Sawamoto, K 2012, Proliferation of neuroblasts in the adult brain: Role of diversin. : Tumors of the Central Nervous System, Volume 9: Lymphoma, Supratentorial Tumors, Glioneuronal Tumors, Gangliogliomas, Neuroblastoma in Adults, Astrocytomas, Ependymomas, Hemangiomas, and Craniopharyngiomas. Springer Netherlands, pp. 177-183. https://doi.org/10.1007/978-94-007-5488-1_20
Hirota Y, Sawamoto K. Proliferation of neuroblasts in the adult brain: Role of diversin. : Tumors of the Central Nervous System, Volume 9: Lymphoma, Supratentorial Tumors, Glioneuronal Tumors, Gangliogliomas, Neuroblastoma in Adults, Astrocytomas, Ependymomas, Hemangiomas, and Craniopharyngiomas. Springer Netherlands. 2012. p. 177-183 https://doi.org/10.1007/978-94-007-5488-1_20
Hirota, Yuki ; Sawamoto, Kazunobu. / Proliferation of neuroblasts in the adult brain : Role of diversin. Tumors of the Central Nervous System, Volume 9: Lymphoma, Supratentorial Tumors, Glioneuronal Tumors, Gangliogliomas, Neuroblastoma in Adults, Astrocytomas, Ependymomas, Hemangiomas, and Craniopharyngiomas. Springer Netherlands, 2012. pp. 177-183
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