Promise of human induced pluripotent stem cells in skin regeneration and investigation

Manabu Ohyama, Hideyuki Okano

研究成果: Article査読

20 被引用数 (Scopus)

抄録

Induced pluripotent stem cell (iPSC) technology has initiated a new era in biomedical science. The skin has been realized as an ideal platform for iPSC applications; unlike other organs, the skin is easily accessible, highly proliferative, and reconstitutable. Currently, skin equivalents can be generated from iPSCs not only from healthy individuals but also from patients with genodermatoses, providing novel platforms for dissecting disease pathophysiology and establishing cell-based therapy. With their developmental plasticity, iPSCs may also enable the regeneration of skin appendages. The iPSC technology may provide novel remedies for intractable disorders, once key issues particularly, safety concerns, are cleared.

本文言語English
ページ(範囲)605-609
ページ数5
ジャーナルJournal of Investigative Dermatology
134
3
DOI
出版ステータスPublished - 2014 3月

ASJC Scopus subject areas

  • 生化学
  • 分子生物学
  • 皮膚病学
  • 細胞生物学

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