Propagating acoustic waves on a culture substrate regulate the directional collective cell migration

Chikahiro Imashiro, Byungjun Kang, Yunam Lee, Youn Hoo Hwang, Seonghun Im, Dae Eun Kim, Kenjiro Takemura, Hyungsuk Lee

研究成果: Article査読

3 被引用数 (Scopus)

抄録

Collective cell migration plays a critical role in physiological and pathological processes such as development, wound healing, and metastasis. Numerous studies have demonstrated how various types of chemical, mechanical, and electrical cues dictate the collective migratory behaviors of cells. Although an acoustic cue can be advantageous because of its noninvasiveness and biocompatibility, cell migration in response to acoustic stimulation remains poorly understood. In this study, we developed a device that is able to apply surface acoustic waves to a cell culture substrate and investigated the effect of propagating acoustic waves on collective cell migration. The migration distance estimated at various wave intensities revealed that unidirectional cell migration was enhanced at a critical wave intensity and that it was suppressed as the intensity was further increased. The increased migration might be attributable to cell orientation alignment along the direction of the propagating wave, as characterized by nucleus shape. Thicker actin bundles indicative of a high traction force were observed in cells subjected to propagating acoustic waves at the critical intensity. Our device and technique can be useful for regulating cellular functions associated with cell migration.

本文言語English
論文番号90
ジャーナルMicrosystems and Nanoengineering
7
1
DOI
出版ステータスPublished - 2021 12月

ASJC Scopus subject areas

  • 原子分子物理学および光学
  • 材料科学(その他)
  • 凝縮系物理学
  • 産業および生産工学
  • 電子工学および電気工学

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