抄録
We previously proposed that membrane permeabilization activity of NSAIDs is involved in NSAID-induced gastric lesions. We here synthesized derivatives of loxoprofen that have lower membrane permeabilization activity than other NSAIDs. Compared to loxoprofen, the derivatives 10a and 10b have lower membrane permeabilization activity and their oral administration produced fewer gastric lesions but showed an equivalent anti-inflammatory effect. These results suggest that 10a and 10b are likely to be therapeutically beneficial as safer NSAIDs.
本文言語 | English |
---|---|
ページ(範囲) | 7879-7882 |
ページ数 | 4 |
ジャーナル | Journal of Medicinal Chemistry |
巻 | 53 |
号 | 21 |
DOI | |
出版ステータス | Published - 2010 11月 11 |
ASJC Scopus subject areas
- 分子医療
- 創薬