Proprotein convertase subtilisin/kexin type 9 is associated with degenerating adipocytes in abdominal aortic aneurysm

Hiroki Tanaka, Kazunori Inuzuka, Yasunori Iida, Hideyuki Shimizu, Naoki Unno, Tetsumei Urano

研究成果: Article

抄録

Abdominal aortic aneurysm (AAA) is a common disease among the elderly. Recently, proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors have been indicated as useful therapeutic tools for the treatment of cardiovascular diseases. The aim of this study was to elucidate the role of PCSK9 in the pathogenesis of AAA. We used fluorescence immunohistochemistry to assess the expression of PCSK9 in aortic tissues resected from 24 patients with AAA. Histological examination showed that PCSK9 expression in the adventitia region of the aneurysms was decreased in AAA samples. In the same region, the expression of CD36 increased. We hypothesized that CD36 expression might upregulate the transport of fatty acids into cells such as the adipocytes, and subsequently cause degradation of the adventitia in the aortic wall, contributing to AAA development.

元の言語English
ページ(範囲)1355-1360
ページ数6
ジャーナルJournal of Oleo Science
67
発行部数10
DOI
出版物ステータスPublished - 2018 1 1

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Proprotein Convertases
Subtilisin
Fatty acids
Fluorescence
Tissue
Degradation
Fatty Acids
Immunohistochemistry

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

これを引用

Proprotein convertase subtilisin/kexin type 9 is associated with degenerating adipocytes in abdominal aortic aneurysm. / Tanaka, Hiroki; Inuzuka, Kazunori; Iida, Yasunori; Shimizu, Hideyuki; Unno, Naoki; Urano, Tetsumei.

:: Journal of Oleo Science, 巻 67, 番号 10, 01.01.2018, p. 1355-1360.

研究成果: Article

Tanaka, Hiroki ; Inuzuka, Kazunori ; Iida, Yasunori ; Shimizu, Hideyuki ; Unno, Naoki ; Urano, Tetsumei. / Proprotein convertase subtilisin/kexin type 9 is associated with degenerating adipocytes in abdominal aortic aneurysm. :: Journal of Oleo Science. 2018 ; 巻 67, 番号 10. pp. 1355-1360.
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AU - Unno, Naoki

AU - Urano, Tetsumei

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