Protection of ischemie myocardium by inhibition of contracture in isolated rat heart

Masato Tani, Hiroshi Hasegawa, Yukako Suganuma, Ken Shinmura, Yoko Kayashi, Yoshiro Nakamura

研究成果: Article査読

31 被引用数 (Scopus)

抄録

Protection of the isch-emic myocardium by pretreatment with a high dose of 2,3-butanedione monoxime (: BDM is attributed to the enhancement of glycolytic ATP production rather than to the inhibition of contracture during mild ischemia. Our objective was to investigate whether the inhibition of contracture would protect the arrested heart during prolonged ischemia. Isolated perfused rat hearts were subjected to 30 min of low-flow ischemia followed by reperfusion. Ischémie hearts were treated with BDM 5 mmol/1 after beating stopped. BDM ameliorated the increase in intraventricular pressure after ischemia without significant changes in ATP levels and with a decreased accumulation of lactate. BDM treatment accelerated the recovery of function and high-energy phosphates with reduced myocardial Ca2+ overload. The results of this study suggested that inhibition of contracture can protect the heart from ischemia-reperfusion injury.

本文言語English
ページ(範囲)H2515-H2519
ジャーナルAmerican Journal of Physiology
271
6 PART 2
出版ステータスPublished - 1996

ASJC Scopus subject areas

  • 生理学(医学)

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