Protective role of HSP70 against various gastrointestinal diseases

Tohru Mizushima

研究成果: Article査読

3 被引用数 (Scopus)

抄録

It is well known that expression of heat shock proteins (HSPs) is induced by various stressors in order to confer protection against such stressors. Stressor-induced tissue damage is involved in various diseases, especially gastrointestinal diseases. In this article, I review our recent work on protective role of HSP70 against gastrointestinal diseases. We obtained genetic evidences that HSP70 is protective against gastric ulcer, inflammatory bowel disease-related colitis and lesions of small intestine. We also suggested that HSP70 could stimulate the ulcer healing. Furthermore, we found that geranylgeranylacetone (non-toxic HSP-inducer) is effective against these diseases. Based on these observations, I propose that non-toxic HSP-inducers are therapeutically beneficial for these diseases.

本文言語English
ページ(範囲)1-5
ページ数5
ジャーナルCurrent Opinion in Pharmacology
19
DOI
出版ステータスPublished - 2014 12

ASJC Scopus subject areas

  • 薬理学
  • 創薬

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