Protective role of JAK/STAT signaling against renal fibrosis in mice with unilateral ureteral obstruction

Kiyomi Koike, Seiji Ueda, Sho ichi Yamagishi, Hideo Yasukawa, Yusuke Kaida, Miyuki Yokoro, Kei Fukami, Akihiko Yoshimura, Seiya Okuda

研究成果: Article

18 被引用数 (Scopus)

抄録

Inflammation is involved in renal fibrosis, a final common pathway for kidney diseases. To clarify how JAK/STAT/SOCS system was involved in renal fibrosis, UUO was induced in BALB/c or SOCS3+/- mice in the presence or absence of JAK inhibitor-incorporated nanoparticle (pyridine6-PGLA). UUO increased pSTAT3 and subsequently elevated SOCS3 levels in the obstructed kidneys. pSTAT3 levels were further increased in SOCS3+/- mice. UUO-induced renal fibrosis was markedly suppressed in SOCS3+/- mice, while it was aggravated by pre-treatment with pyridine6-PGLA. Although there were no differences in renal mRNA levels of TGF-β and collagens between wild and SOCS3+/- mice, MMP-2 activity was enhanced in SOCS3+/- UUO mice. Activated MMP-2 was completely suppressed by pyridine6-PGLA-pre-treatment. TNF-α one of JAK/STAT activators, increased pSTAT3 levels and subsequently induced MMP-2 activation in proximal tubular cells. These results suggest that JAK/STAT3 signaling may play a role in repair process of renal fibrosis in UUO partly via MMP-2 activation.

本文言語English
ページ(範囲)78-87
ページ数10
ジャーナルClinical Immunology
150
1
DOI
出版ステータスPublished - 2014 1 1

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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