Protective roles of transsulfuration against methionine toxicity

Shotaro Kamata, Isao Ishii

研究成果: Chapter

1 被引用数 (Scopus)

抄録

Methionine is an essential amino acid in mammals, but is the most toxic among the constituent amino acids of proteins. Excessive methionine intake causes oxidative/nitrosative injuries in the liver, hepatic/splenic hypertrophy, altered erythrocyte morphology, and the resultant splenic hemosiderosis in rats; however, the pathophysiology of methionine-induced liver toxicity remains to be elucidated. Methionine can be metabolized into cysteine by methionine cycle and transsulfuration, and cysteine can be further metabolized into cytoprotective metabolites such as glutathione, taurine, and hydrogen sulfide (H2S). We recently found that a methionine-rich diet induces acute lethal hepatitis in transsulfuration-defective cystathionine γ-lyase-deficient mice. Molecular mechanisms by which methionine excess induces hepatic dysfunction and physiological roles of transsulfuration in its detoxification (metabolism) are herein reviewed.

本文言語English
ホスト出版物のタイトルMethionine
ホスト出版物のサブタイトルBiosynthesis, Chemical Structure and Toxicity
出版社Nova Science Publishers, Inc.
ページ143-153
ページ数11
ISBN(印刷版)9781626182462
出版ステータスPublished - 2013 4 1

ASJC Scopus subject areas

  • 生化学、遺伝学、分子生物学(全般)

フィンガープリント

「Protective roles of transsulfuration against methionine toxicity」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル