抄録
P-glycoprotein (P-gp)/ABCB1 is a key molecule of multidrug resistance in cancer. Protein phosphatase (PP) 2A, regulatory subunit B, gamma (PPP2R3C), which is a regulatory subunit of PP2A and PP5, was identified as a binding candidate to P-gp. Immunoprecipitation-western blotting revealed that PP5 and PPP2R3C were coprecipitated with P-gp, while PP2A was not. PP5/PPP2R3C dephosphorylated protein kinase A/protein kinase C-phosphorylation of P-gp. Knockdown of PP5 and/or PPP2R3C increased P-gp expression and lowered the sensitivity to vincristine and doxorubicin. Consequently, our results indicate that PP5/PPP2R3C negatively regulates P-gp expression and function.
本文言語 | English |
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ページ(範囲) | 124-131 |
ページ数 | 8 |
ジャーナル | Cancer Letters |
巻 | 345 |
号 | 1 |
DOI | |
出版ステータス | Published - 2014 4月 1 |
ASJC Scopus subject areas
- 腫瘍学
- 癌研究