Pulmonary epithelial cell maturation in hyperplastic lungs associated with fetal tracheal agenesis

Kazuhiro Mori, Kazushige Ikeda, Shinya Hayashida, Keisuke Tokieda, Hitoshi Ishimoto, Yoshihiro Fujii, Ryuji Fukuzawa, Yoshihiro Kitano

研究成果: Article

3 引用 (Scopus)

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Background/Purpose: Cellular differentiation of pulmonary hyperplasia has not been reported in human cases. The authors studied surfactant protein expression and ultrastructure of pulmonary epithelial cells in fetal hyperplastic lungs associated with congenital tracheal agenesis. Methods: The maturation of pulmonary epithelial cells was assessed by immunohistochemical examination for surfactant proteins (SP-A, mature SP-B, proSP-B, proSP-C, and SP-D) and transmission electron microscopy. As controls normal lung portions of 8 fetuses born at 21 weeks gestation were used. Results: Mature SP-B and SP-D was detected in terminal airways in this case, but not in controls. In electron microscopy, lamellar bodies were recognized, and glycogen granules were less abundant in terminal airway cells. Conclusion: The differentiation of pulmonary epithelial cells appeared to be more advanced for the gestational age in pulmonary hyperplasia with congenital tracheal agenesis.

元の言語English
ページ(範囲)1845-1848
ページ数4
ジャーナルJournal of Pediatric Surgery
36
発行部数12
DOI
出版物ステータスPublished - 2001

ASJC Scopus subject areas

  • Surgery
  • Pediatrics, Perinatology, and Child Health

フィンガープリント Pulmonary epithelial cell maturation in hyperplastic lungs associated with fetal tracheal agenesis' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

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    Mori, K., Ikeda, K., Hayashida, S., Tokieda, K., Ishimoto, H., Fujii, Y., Fukuzawa, R., & Kitano, Y. (2001). Pulmonary epithelial cell maturation in hyperplastic lungs associated with fetal tracheal agenesis. Journal of Pediatric Surgery, 36(12), 1845-1848. https://doi.org/10.1053/jpsu.2001.28862