Pulmonary neuroendocrine tumors with nuclear inclusion

Saori Kobayashi, Koji Tsuta, Shigeki Sekine, Akihiko Yoshida, Naoshi Sasaki, Yasuo Shibuki, Hiroyuki Sakurai, Shun ichi Watanabe, Hisao Asamura, Hitoshi Tsuda

研究成果: Article

1 引用 (Scopus)

抄録

Nuclear inclusion or pseudoinclusion is a peculiar cytological feature, and its recognition in appropriate clinicopathological settings can aid in the diagnosis of several disease entities. To the best of our knowledge, only 1 case of pulmonary neuroendocrine tumor (NET) with nuclear pseudoinclusion has been reported. A review of 227 patients who had undergone surgical resection for pulmonary NETs revealed 2 tumors with different mechanisms of nuclear inclusion. To explore the cause of nuclear inclusion, NET with nuclear inclusion was characterized immunohistochemically and ultrastructurally. Nuclear inclusions were observed in 2 of the 227 (0.9%) patients with pulmonary NETs. The first patient was a 46-year-old woman with small cell carcinoma. Tumor cells with nuclear inclusions were distributed focally. Ultrastructural analysis showed that these inclusions were pseudoinclusions. The second patient was a 62-year-old man with large-cell neuroendocrine carcinoma. Nuclear inclusions were observed in the focal area of the tumor. Immunohistochemical analysis revealed that the intra-nuclear materials consisted of biotin and aberrant cytoplasmic and nuclear accumulation of β-catenin. Mutational analysis revealed a CTNNB1 gene mutation.

元の言語English
ページ(範囲)574-577
ページ数4
ジャーナルPathology Research and Practice
209
発行部数9
DOI
出版物ステータスPublished - 2013 9
外部発表Yes

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Intranuclear Inclusion Bodies
Neuroendocrine Tumors
Lung
Neuroendocrine Carcinoma
Large Cell Carcinoma
Catenins
Neoplasms
Small Cell Carcinoma
Biotin
Mutation
Genes

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Cell Biology

これを引用

Kobayashi, S., Tsuta, K., Sekine, S., Yoshida, A., Sasaki, N., Shibuki, Y., ... Tsuda, H. (2013). Pulmonary neuroendocrine tumors with nuclear inclusion. Pathology Research and Practice, 209(9), 574-577. https://doi.org/10.1016/j.prp.2013.06.016

Pulmonary neuroendocrine tumors with nuclear inclusion. / Kobayashi, Saori; Tsuta, Koji; Sekine, Shigeki; Yoshida, Akihiko; Sasaki, Naoshi; Shibuki, Yasuo; Sakurai, Hiroyuki; Watanabe, Shun ichi; Asamura, Hisao; Tsuda, Hitoshi.

:: Pathology Research and Practice, 巻 209, 番号 9, 09.2013, p. 574-577.

研究成果: Article

Kobayashi, S, Tsuta, K, Sekine, S, Yoshida, A, Sasaki, N, Shibuki, Y, Sakurai, H, Watanabe, SI, Asamura, H & Tsuda, H 2013, 'Pulmonary neuroendocrine tumors with nuclear inclusion', Pathology Research and Practice, 巻. 209, 番号 9, pp. 574-577. https://doi.org/10.1016/j.prp.2013.06.016
Kobayashi S, Tsuta K, Sekine S, Yoshida A, Sasaki N, Shibuki Y その他. Pulmonary neuroendocrine tumors with nuclear inclusion. Pathology Research and Practice. 2013 9;209(9):574-577. https://doi.org/10.1016/j.prp.2013.06.016
Kobayashi, Saori ; Tsuta, Koji ; Sekine, Shigeki ; Yoshida, Akihiko ; Sasaki, Naoshi ; Shibuki, Yasuo ; Sakurai, Hiroyuki ; Watanabe, Shun ichi ; Asamura, Hisao ; Tsuda, Hitoshi. / Pulmonary neuroendocrine tumors with nuclear inclusion. :: Pathology Research and Practice. 2013 ; 巻 209, 番号 9. pp. 574-577.
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