Pulmonary pleomorphic carcinoma producing granulocyte-macrophage colony-stimulating factor: Report of a case

Toshinori Fukutomi, Mitsutomo Kohno, Yotaro Izumi, Masazumi Watanabe, Yuichiro Hayashi, Hiroaki Nomori

研究成果: Article査読

9 被引用数 (Scopus)

抄録

We report a case of lung cancer producing granulocyte-macrophage colony-stimulating factor (GM-CSF). The patient, a 55-year-old woman, was found to have leukocytosis (leukocytes 28.8 × 10 3/mm 3) with eosinophilia (eosinophils 24.5%) without any evidence of infection or allergy. The serum concentration of GM-CSF was elevated to 44 pg/ml (normal range <2.0 pg/ml), which might have induced the leukocytosis and eosinophilia. We performed left pneumonectomy and diagnosed a pleomorphic carcinoma with p-T2bN0M0, based on histological examination of the resected tumor. Immunohistochemical examination revealed GM-CSF. The serum level of GM-CSF decreased to within the normal range 8 days after surgery. At the time of writing, 16 months after the surgery, she was alive without disease. To our knowledge, this represents the first case report of a GM-CSF-producing tumor effectively treated by surgical resection.

本文言語English
ページ(範囲)288-291
ページ数4
ジャーナルSurgery today
42
3
DOI
出版ステータスPublished - 2012 2月 1

ASJC Scopus subject areas

  • 外科

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