Pulsed amperometry for anti-fouling of boron-doped diamond in electroanalysis of β-agonists: Application to flow injection for pharmaceutical analysis

Chanpen Karuwan, Thitirat Mantim, Patcharin Chaisuwan, Prapin Wilairat, Kate Grudpan, Piyada Jittangprasert, Yasuaki Einaga, Orawon Chailapakul, Leena Suntornsuk, Oraphan Anurukvorakun, Duangjai Nacapricha

研究成果: Article査読

26 被引用数 (Scopus)

抄録

This work presents the construction and application of boron-doped diamond (BDD) thin film electrode as sensor for the determination of three β-agonists, viz. salbutamol, terbutaline and clenbuterol. Although well-known as a chemically inert material, BDD film however shows fouling in detection of these compounds using fixed-potential mode amperometry. A suitable waveform for pulsed amperometric detection (PAD) was developed and used to determine the agonist compounds. It was seen that the developed PAD significantly refreshed the BDD surface for long-term detection in flow injection analysis. Linear working ranges were 0.5-100 μM, 1.0-100 μM and 0.5-50 μM for salbutamol, terbutaline and clenbuterol, respectively. The developed PAD-BDD system was applied to successfully determine salbutamol and terbutaline in commercial pharmaceutical products. The methods were validated with a capillary electrophoresis method.

本文言語English
ページ(範囲)1837-1850
ページ数14
ジャーナルSensors
6
12
DOI
出版ステータスPublished - 2006 12

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Atomic and Molecular Physics, and Optics
  • Instrumentation
  • Electrical and Electronic Engineering

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