Purified opioid μ-receptor is of a different molecular size than δ- and κ-receptors

Hiroshi Ueda, Hitoshi Harada, Hidemi Misawa, Masakatsu Nozaki, Hiroshi Takagi

研究成果: Article査読

18 被引用数 (Scopus)

抄録

Opioid μ-receptors were solubilized from rat brains with 0.5% Triton X-100 in the presence of 0.32 M sucrose and then purified with 6-succinyl morphine-Affi-Gel 102 column. Purified materials showed a major band with mol.wt. 58,000 Da and a minor band with mol.wt. 41,000 Da. Affinity cross linking with [3H]DAGO, a selective μ-opioid agonist, to the neural membranes and purified materials revealed that opioid μ-binding protein has a mol.wt. of 58,000 Da, a value totally different from that of δ- (mol.wt. 18,500 Da) and κ- (mol.wt. 36,600 Da) binding protein.

本文言語English
ページ(範囲)339-344
ページ数6
ジャーナルNeuroscience Letters
75
3
DOI
出版ステータスPublished - 1987 4 10
外部発表はい

ASJC Scopus subject areas

  • 神経科学(全般)

フィンガープリント

「Purified opioid μ-receptor is of a different molecular size than δ- and κ-receptors」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル