Purkinje Cell Dendrites: The Time-Tested Icon in Histology

Yukari H. Takeo, Michisuke Yuzaki

研究成果: Chapter

抄録

Neurons develop a wide variety of cell-type-specific shapes of dendrites. Nevertheless, the underlying mechanisms remain largely unclear in the mammalian central nervous system in vivo mainly due to the difficulty in observing and manipulating the rapid and non-synchronous changes in dendritic shapes during development. Cerebellar Purkinje cells (PCs), which slowly develop dendrites over several postnatal weeks in a relatively stereotypical manner, have provided an excellent model system. Recent genetic tools have identified two principles that specify the dendritic morphology of PCs. First, the same molecule, such as RORα, T3, and PGC-1α, could exert distinct functions at different developmental stages. Second, competition between dendrites from the same or neighboring PCs likely regulates the extensions of dendrites and their planarity. Furthermore, neuronal activities likely contribute to the maturation and stabilization of dendrites. Future studies are warranted to clarify whether and how defective dendritic growth is related to the pathology of PCs in certain neurological disorders.

本文言語English
ホスト出版物のタイトルContemporary Clinical Neuroscience
出版社Springer Nature
ページ145-167
ページ数23
DOI
出版ステータスPublished - 2021

出版物シリーズ

名前Contemporary Clinical Neuroscience
ISSN(印刷版)2627-535X
ISSN(電子版)2627-5341

ASJC Scopus subject areas

  • 行動神経科学
  • 認知神経科学
  • 神経学
  • 感覚系
  • 臨床神経学

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