Pyripyropenes, novel inhibitors of acyl-coa: Cholesterol acyltransferase produced by aspergillus fumigatus. II. Structure elucidation of pyripyropenes A, B, C and D

Young Kook Kim, Hiroshi Tomoda, Hiroyuki Nishida, Toshiaki Sunazuka, Rika Obata, Satoshi Omura

研究成果: Article

88 引用 (Scopus)

抜粋

The structures of pyripyropenes A, B, C and D, novel acyl-CoA : cholesterol acyltransferase (ACAT) inhibitors, were determined mainly by spectroscopic studies including various NMR measurements. Pyripyropenes have a common structure which consists of pyridine, α-pyrone and sesquiterpene moieties. One of the three O-acetyl residues in the sesquiterpene moiety of pyripyropene A is replaced with an O-propionyl residue in pyripyropenes B, C and D.

元の言語English
ページ(範囲)154-162
ページ数9
ジャーナルThe Journal of Antibiotics
47
発行部数2
DOI
出版物ステータスPublished - 1994 1 1

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ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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