Quantitative analysis of the interactions between 3d hepatocyte tissue and capillary networks in a microfluidic platform

Tomohiro Tsuji, Seok Chung, Roger Kamm, Mariko Ikeda, Kazuo Tanishita, Ryo Sudo

研究成果: Conference contribution

抄録

Tissue vascularization is one of the biggest challenges in tissue engineering. We constructed 3D hepatocyte tissue-like structures and endothelial capillary networks in a microfluidic platform. Here, we analyzed interactions between these structures quantitatively by recording the cell migration and morphogenesis. The analysis of capillary network extension rate under various combinations of growth factors (e.g., HGF, VEGF) revealed that the growth rate significantly increased by the growth factor addition. The capillary networks, however, stopped extending after contacting with hepatocytes, suggesting that additional factors are necessary for achieving hepatocyte tissue-like structures including microvascular networks.

本文言語English
ホスト出版物のタイトル15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
ページ1529-1531
ページ数3
出版ステータスPublished - 2011 12月 1
イベント15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011 - Seattle, WA, United States
継続期間: 2011 10月 22011 10月 6

出版物シリーズ

名前15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
3

Other

Other15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
国/地域United States
CitySeattle, WA
Period11/10/211/10/6

ASJC Scopus subject areas

  • 制御およびシステム工学

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