Quinotrierixin inhibited ER stress-induced XBPl mRNA splicing through inhibition of protein synthesis

Kohta Yamamoto, Etsu Tashiro, Masaya Imoto

研究成果: Article査読

13 被引用数 (Scopus)

抄録

Quinotrierixin was isolated from microbes as an inhibitor of ER stress-induced XBPl mRNA splicing, but its mode of action was unclear. We found that quinotrierixin is an inhibitor of protein synthesis, and that the required dose range of quinotrierixin to inhibit ER stress-induced XBPl mRNA splicing was similar to that to inhibit protein synthesis. Furthermore, we also found that quinotrierixin inhibited the ER stress-induced increases of unfolded protein response-related genes such as GRP78, CHOP, EDEM, ERdj4, and p58IPK. Thus, we showed that quinotrierixin inhibited the ER stress-induced unfolded protein response, possibly due to its inhibitory activity of protein synthesis.

本文言語English
ページ(範囲)284-288
ページ数5
ジャーナルBioscience, Biotechnology and Biochemistry
75
2
DOI
出版ステータスPublished - 2011

ASJC Scopus subject areas

  • バイオテクノロジー
  • 分析化学
  • 生化学
  • 応用微生物学とバイオテクノロジー
  • 分子生物学
  • 有機化学

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