Radiation Injury after Hypofractionated Stereotactic Radiotherapy for Peripheral Small Lung Tumors: Serial Changes on CT

Toshiaki Takeda, Atsuya Takeda, Etsuo Kunieda, Akitoshi Ishizaka, Kazuhiko Takemasa, Kyoko Shimada, Seika Yamamoto, Naoyuki Shigematsu, Osamu Kawaguchi, Jun Ichi Fukada, Toshio Ohashi, Sachio Kuribayashi, Atsushi Kubo

研究成果: Article

79 引用 (Scopus)

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OBJECTIVE. We studied the serial changes and CT manifestations of pulmonary radiation injury after hypofractionated stereotactic radiation therapy for peripheral small lung tumors. SUBJECTS AND METHODS. Hypofractionated stereotactic radiation therapy was applied to 20 patients with proven primary (n = 11) or metastatic (n = 9) lung cancer, for a total of 22 lesions of 3 cm or less in diameter located within 3 cm from the parietal pleural surface. Follow-up CT was scheduled at 1 and 3 months, and every 3 months thereafter. RESULTS. Ground-glass opacities were observed around four (18%) of 22 lesions at 3-6 months. The opacities nearly corresponded to the planned target volume, but half of them were unevenly distributed. Ground-glass opacities gradually disappeared or evolved into dense consolidation while shrinking. Dense consolidations developed in 16 (73%) of 22 lesions, including seven in the center of the planned target volume and nine in the periphery of the planned target volume. Dense consolidations moved in six of these 16 lesions and gradually shrank, becoming fixed as solid or linear opacities approximately 12 months later. CONCLUSION. The pulmonary opacities observed after hypofractionated stereotactic radiation therapy for peripheral small lung tumors may not precisely correspond to the planned target volume (unlike those with conventional radiation therapy) and may change in shape and location dynamically during the first year. Knowledge of these findings is necessary to avoid misunderstandings concerning tumor regrowth or new tumors.

元の言語English
ページ(範囲)1123-1128
ページ数6
ジャーナルAmerican Journal of Roentgenology
182
発行部数5
DOI
出版物ステータスPublished - 2004 5

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

フィンガープリント Radiation Injury after Hypofractionated Stereotactic Radiotherapy for Peripheral Small Lung Tumors: Serial Changes on CT' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

  • これを引用

    Takeda, T., Takeda, A., Kunieda, E., Ishizaka, A., Takemasa, K., Shimada, K., Yamamoto, S., Shigematsu, N., Kawaguchi, O., Fukada, J. I., Ohashi, T., Kuribayashi, S., & Kubo, A. (2004). Radiation Injury after Hypofractionated Stereotactic Radiotherapy for Peripheral Small Lung Tumors: Serial Changes on CT. American Journal of Roentgenology, 182(5), 1123-1128. https://doi.org/10.2214/ajr.182.5.1821123