Radiopaque and biodegradable beads fabricated with Lipiodol and polycaprolactone for transarterial chemoembolization

Yutaka Okamoto, Kenta Bito, Terumitsu Hasebe, Tomohiro Matsumoto, Atsushi Hotta

研究成果: Article査読

抄録

Embolic beads for transarterial chemoembolization (TACE) should possess radiopacity and biodegradability at the same time, to be visualized in a body under fluoroscopy and CT scanning to avoid complicating disease. In this study, we fabricated radiopaque and biodegradable beads composed of Lipiodol (LPD) (ethiodized oil) and polycaprolactone (PCL), a biocompatible and biodegradable polymer. LPD/PCL beads were first fabricated with a home-made microfluidic device. By changing the flow-rate ratio in the microfluidic device, the mean diameter of LPD/PCL beads could be well controlled. The radiopacity was evaluated by the fluoroscopic imaging and the CT number measurements. Furthermore, the biodegradability was evaluated by collecting the weight loss data of LPD/PCL immersed in lipase/PBS solution and PBS. The results showed that LPD/PCL beads obtained in this study had sufficient radiopacity and biodegradability, which would be an alternative embolic agent for TACE.

本文言語English
ページ(範囲)1187-1192
ページ数6
ジャーナルMRS Advances
4
20
DOI
出版ステータスPublished - 2019

ASJC Scopus subject areas

  • 機械工学
  • 材料力学
  • 材料科学(全般)
  • 凝縮系物理学

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