Radiopaque and biodegradable beads fabricated with Lipiodol and polycaprolactone for transarterial chemoembolization

Yutaka Okamoto, Kenta Bito, Terumitsu Hasebe, Tomohiro Matsumoto, Atsushi Hotta

研究成果: Article

抜粋

Embolic beads for transarterial chemoembolization (TACE) should possess radiopacity and biodegradability at the same time, to be visualized in a body under fluoroscopy and CT scanning to avoid complicating disease. In this study, we fabricated radiopaque and biodegradable beads composed of Lipiodol (LPD) (ethiodized oil) and polycaprolactone (PCL), a biocompatible and biodegradable polymer. LPD/PCL beads were first fabricated with a home-made microfluidic device. By changing the flow-rate ratio in the microfluidic device, the mean diameter of LPD/PCL beads could be well controlled. The radiopacity was evaluated by the fluoroscopic imaging and the CT number measurements. Furthermore, the biodegradability was evaluated by collecting the weight loss data of LPD/PCL immersed in lipase/PBS solution and PBS. The results showed that LPD/PCL beads obtained in this study had sufficient radiopacity and biodegradability, which would be an alternative embolic agent for TACE.

元の言語English
ページ(範囲)1187-1192
ページ数6
ジャーナルMRS Advances
4
発行部数20
DOI
出版物ステータスPublished - 2019 1 1

ASJC Scopus subject areas

  • Mechanical Engineering
  • Mechanics of Materials
  • Materials Science(all)
  • Condensed Matter Physics

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