TY - JOUR
T1 - Randomized controlled trial of laparoscopic versus open colectomy for advanced colorectal cancer
AU - Hasegawa, H.
AU - Kabeshima, Y.
AU - Watanabe, M.
AU - Yamamoto, S.
AU - Kitajima, M.
PY - 2003/4/1
Y1 - 2003/4/1
N2 - Background: After confirming a favorable outcome of laparoscopic surgery for early colorectal cancer, we conducted a randomized controlled trial to compare short-term outcomes of laparoscopic and open colectomy for advanced colorectal cancer. Methods: Fifty-nine patients with T2 or T3 colorectal cancer were randomized to undergo laparoscopic (n = 29) or open (n = 30) colectomy. Median follow-up was 20 months (range, 6-34 months). Results: Operative time was longer (p < 0.0001) and blood loss (p = 0.0034) and postoperative analgesic requirement were less in the laparoscopic group than in the open group. An earlier return of bowel motility and earlier discharge from the hospital (p = 0.0164) were observed after laparoscopic surgery. Serum C-reactive protein levels on postoperative days 1 (p < 0.0001) and 4 (p = 0.0039) were lower in the laparoscopic group than in the open group. Postoperative complications did not differ between the two groups. Conclusion: Laparoscopic surgery for advanced colorectal cancer is feasible, with favorable short-term outcome.
AB - Background: After confirming a favorable outcome of laparoscopic surgery for early colorectal cancer, we conducted a randomized controlled trial to compare short-term outcomes of laparoscopic and open colectomy for advanced colorectal cancer. Methods: Fifty-nine patients with T2 or T3 colorectal cancer were randomized to undergo laparoscopic (n = 29) or open (n = 30) colectomy. Median follow-up was 20 months (range, 6-34 months). Results: Operative time was longer (p < 0.0001) and blood loss (p = 0.0034) and postoperative analgesic requirement were less in the laparoscopic group than in the open group. An earlier return of bowel motility and earlier discharge from the hospital (p = 0.0164) were observed after laparoscopic surgery. Serum C-reactive protein levels on postoperative days 1 (p < 0.0001) and 4 (p = 0.0039) were lower in the laparoscopic group than in the open group. Postoperative complications did not differ between the two groups. Conclusion: Laparoscopic surgery for advanced colorectal cancer is feasible, with favorable short-term outcome.
KW - Colorectal cancer
KW - Laparoscopic surgery
KW - Randomized controlled trial
KW - Short-term outcome
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U2 - 10.1007/s00464-002-8516-4
DO - 10.1007/s00464-002-8516-4
M3 - Article
C2 - 12574925
AN - SCOPUS:0037380511
SN - 0930-2794
VL - 17
SP - 636
EP - 640
JO - Surgical Endoscopy and Other Interventional Techniques
JF - Surgical Endoscopy and Other Interventional Techniques
IS - 4
ER -
