Rapid decline in renal function after acute myocardial infarction

Yusuke Mashima, Tsuneo Konta, Kazunobu Ichikawa, Ami Ikeda, Kazuko Suzuki, Masahiro Wanezaki, Satoshi Nishiyama, Tetsu Watanabe, Isao Kubota

研究成果: Article

4 引用 (Scopus)


Aim: To investigate the long term effects of cardiac events on renal function, a prospective study of patients with acute myocardial infarction was conducted. Methods: A total of 137 patients with acute myocardial infarction were followed for 1 year. The change of estimated glomerular filtration rate (eGFR) in cardiac patients was compared with that in background-matched controls, and the factors associated with eGFR changes were analyzed. Results: The eGFR decrease was much larger after myocardial infarction, from 73.7 ± 1.9 ml/ min/1.73 m2 (mean ± SEM) at baseline to 64.7 ± 1.7 at 1 year, (p <0.001), compared with that of controls (from 72.8 ± 1.2 to 72.1 ± 1.3, p = 0.305). Multiple regression analysis showed that eGFR change was associated negatively with age, baseline eGFR, proteinuria, and positively with the administration of angiotensin converting enzyme inhibitors or angiotensin II receptor blockers, but not the severity of cardiac damage and comorbidities. Longitudinal analysis 1 year before and 2 years after myocardial infarction showed that eGFR decrease was larger during baseline and 6 months after the event (-7.0 ± 1.0). Conclusions: Renal decline was rapid after myocardial infarction and was affected by clinical characteristics of patients. Careful follow-up of renal function is recommended to prevent the progression of renal and cardiac disease

ジャーナルClinical Nephrology
出版物ステータスPublished - 2013 2 19

ASJC Scopus subject areas

  • Nephrology

フィンガープリント Rapid decline in renal function after acute myocardial infarction' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

  • これを引用

    Mashima, Y., Konta, T., Ichikawa, K., Ikeda, A., Suzuki, K., Wanezaki, M., Nishiyama, S., Watanabe, T., & Kubota, I. (2013). Rapid decline in renal function after acute myocardial infarction. Clinical Nephrology, 79(1), 15-20. https://doi.org/10.5414/CN107645