Rational design and synthesis of novel heparan sulfate mimetic compounds as antiadhesive agents

Keisuke Ishida; Siro Simizu; Takayuki Teruya; Michal K. Wierzba; Hiroyuki Osada

doi:10.1016/j.bmcl.2004.03.009

Rational design and synthesis of novel heparan sulfate mimetic compounds as antiadhesive agents

Keisuke Ishida, Siro Simizu, Takayuki Teruya, Michal K. Wierzba, Hiroyuki Osada

研究成果: Article › 査読

2 被引用数 (Scopus)

抄録

A biological evaluation of the antiadhesive activity of novel heparan sulfate glycosaminoglycans mimetic compounds (KI-compounds) is described. In an adhesion assay, KI-111 [2-(4-fluoro-3-nitrobenzoyl)benzoic acetic anhydride] was found to exert potent inhibitory activities against the adhesion of human fibrosarcoma HT1080 cells and HeLa cells to fibronectin. Cell growth, migration, and invasion of HT1080 cells were also inhibited by KI-111 at almost equal concentrations.

本文言語	English
ページ（範囲）	2505-2509
ページ数	5
ジャーナル	Bioorganic and Medicinal Chemistry Letters
巻	14
号	10
DOI	https://doi.org/10.1016/j.bmcl.2004.03.009
出版ステータス	Published - 2004 5月 17
外部発表	はい

ASJC Scopus subject areas

生化学
分子医療
分子生物学
薬科学
創薬
臨床生化学
有機化学

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10.1016/j.bmcl.2004.03.009

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title = "Rational design and synthesis of novel heparan sulfate mimetic compounds as antiadhesive agents",

abstract = "A biological evaluation of the antiadhesive activity of novel heparan sulfate glycosaminoglycans mimetic compounds (KI-compounds) is described. In an adhesion assay, KI-111 [2-(4-fluoro-3-nitrobenzoyl)benzoic acetic anhydride] was found to exert potent inhibitory activities against the adhesion of human fibrosarcoma HT1080 cells and HeLa cells to fibronectin. Cell growth, migration, and invasion of HT1080 cells were also inhibited by KI-111 at almost equal concentrations.",

keywords = "Antitumor, Drug design, Heparan sulfate mimetic",

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AU - Ishida, Keisuke

AU - Simizu, Siro

AU - Teruya, Takayuki

AU - Wierzba, Michal K.

AU - Osada, Hiroyuki

N1 - Funding Information: This study was supported in part by a Grant-in-Aid from the Ministry of Education, Science, Sports, Culture and Technology of Japan, and by the Chemical Biology Project (RIKEN).

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Y1 - 2004/5/17

N2 - A biological evaluation of the antiadhesive activity of novel heparan sulfate glycosaminoglycans mimetic compounds (KI-compounds) is described. In an adhesion assay, KI-111 [2-(4-fluoro-3-nitrobenzoyl)benzoic acetic anhydride] was found to exert potent inhibitory activities against the adhesion of human fibrosarcoma HT1080 cells and HeLa cells to fibronectin. Cell growth, migration, and invasion of HT1080 cells were also inhibited by KI-111 at almost equal concentrations.

AB - A biological evaluation of the antiadhesive activity of novel heparan sulfate glycosaminoglycans mimetic compounds (KI-compounds) is described. In an adhesion assay, KI-111 [2-(4-fluoro-3-nitrobenzoyl)benzoic acetic anhydride] was found to exert potent inhibitory activities against the adhesion of human fibrosarcoma HT1080 cells and HeLa cells to fibronectin. Cell growth, migration, and invasion of HT1080 cells were also inhibited by KI-111 at almost equal concentrations.

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KW - Drug design

KW - Heparan sulfate mimetic

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JO - Bioorganic and Medicinal Chemistry Letters

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Rational design and synthesis of novel heparan sulfate mimetic compounds as antiadhesive agents

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