Rationale and design of J-ACCESS 4: Prognostic impact of reducing myocardial ischemia identified using ECG-gated myocardial perfusion SPECT in Japanese patients with coronary artery disease

Mamoru Nanasato, Kenichi Nakajima, Hiroshi Fujita, Kan Zen, Shun Kosaka, Akiyoshi Hashimoto, Masao Moroi, Shigeru Fukuzawa, Taishiro Chikamori, Shigeyuki Nishimura, Akira Yamashina, Hideo Kusuoka, Atsushi Hirayama, Tsunehiko Nishimura

研究成果: Article

9 引用 (Scopus)

抄録

Background: The findings of our recent study entitled, "Japanese Assessment of Cardiac Events and Survival Study by Quantitative Gated SPECT (J-ACCESS)" showed that myocardial perfusion single photon emission computed tomography (MPS) can detect coronary artery disease (CAD) and help to predict future cardiac events in patients with suspected or extant CAD. However, the extent of the benefit conferred by percutaneous coronary intervention (PCI) as an initial management strategy compared with optimal medical therapy remains controversial. Little evidence supports the notion that myocardial ischemia identified using MPS is an alternative target of coronary revascularization to reduce the likelihood of developing cardiac events. Methods: The multicenter, prospective cohort J-ACCESS 4 study aims to clarify the prognostic impact of reducing myocardial ischemia determined using electrocardiogram-gated MPS in Japanese patients with coronary artery disease. We started to register patients in J-ACCESS 4 at 74 facilities during June 2012 and will continue to do so until December 2013 or until the cohort comprises 500 patients who will participate in the study from one month before, until two months after stress/rest MPS assessment. Imaging data, the background of the patients including coronary risk factors and treatment before MPS assessments will be analyzed. The patients will undergo coronary revascularization within two months after MPS and/or receive appropriate medical therapy. The second stress/rest MPS will be performed from 4 to 10 months after coronary revascularization or registration. They will be followed up for over one year after the second MPS assessment. The primary endpoints will be cardiac death, sudden death of unknown cause, non-fatal myocardial infarction, and hospitalization for heart failure. The secondary endpoints will comprise death due to all causes including non-cardiac death and any cardiovascular events. This study will be completed in 2015. Here, we describe the design of the J-ACCESS 4 study.

元の言語English
ページ(範囲)159-164
ページ数6
ジャーナルJournal of Cardiology
63
発行部数2
DOI
出版物ステータスPublished - 2014 2

Fingerprint

Single-Photon Emission-Computed Tomography
Myocardial Ischemia
Coronary Artery Disease
Electrocardiography
Perfusion
Percutaneous Coronary Intervention
Sudden Death
Hospitalization
Therapeutics
Heart Failure
Myocardial Infarction
Survival

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

これを引用

Rationale and design of J-ACCESS 4 : Prognostic impact of reducing myocardial ischemia identified using ECG-gated myocardial perfusion SPECT in Japanese patients with coronary artery disease. / Nanasato, Mamoru; Nakajima, Kenichi; Fujita, Hiroshi; Zen, Kan; Kosaka, Shun; Hashimoto, Akiyoshi; Moroi, Masao; Fukuzawa, Shigeru; Chikamori, Taishiro; Nishimura, Shigeyuki; Yamashina, Akira; Kusuoka, Hideo; Hirayama, Atsushi; Nishimura, Tsunehiko.

:: Journal of Cardiology, 巻 63, 番号 2, 02.2014, p. 159-164.

研究成果: Article

Nanasato, M, Nakajima, K, Fujita, H, Zen, K, Kosaka, S, Hashimoto, A, Moroi, M, Fukuzawa, S, Chikamori, T, Nishimura, S, Yamashina, A, Kusuoka, H, Hirayama, A & Nishimura, T 2014, 'Rationale and design of J-ACCESS 4: Prognostic impact of reducing myocardial ischemia identified using ECG-gated myocardial perfusion SPECT in Japanese patients with coronary artery disease', Journal of Cardiology, 巻. 63, 番号 2, pp. 159-164. https://doi.org/10.1016/j.jjcc.2013.07.006
Nanasato, Mamoru ; Nakajima, Kenichi ; Fujita, Hiroshi ; Zen, Kan ; Kosaka, Shun ; Hashimoto, Akiyoshi ; Moroi, Masao ; Fukuzawa, Shigeru ; Chikamori, Taishiro ; Nishimura, Shigeyuki ; Yamashina, Akira ; Kusuoka, Hideo ; Hirayama, Atsushi ; Nishimura, Tsunehiko. / Rationale and design of J-ACCESS 4 : Prognostic impact of reducing myocardial ischemia identified using ECG-gated myocardial perfusion SPECT in Japanese patients with coronary artery disease. :: Journal of Cardiology. 2014 ; 巻 63, 番号 2. pp. 159-164.
@article{db5722ec186f4eb29534c815f829b97a,
title = "Rationale and design of J-ACCESS 4: Prognostic impact of reducing myocardial ischemia identified using ECG-gated myocardial perfusion SPECT in Japanese patients with coronary artery disease",
abstract = "Background: The findings of our recent study entitled, {"}Japanese Assessment of Cardiac Events and Survival Study by Quantitative Gated SPECT (J-ACCESS){"} showed that myocardial perfusion single photon emission computed tomography (MPS) can detect coronary artery disease (CAD) and help to predict future cardiac events in patients with suspected or extant CAD. However, the extent of the benefit conferred by percutaneous coronary intervention (PCI) as an initial management strategy compared with optimal medical therapy remains controversial. Little evidence supports the notion that myocardial ischemia identified using MPS is an alternative target of coronary revascularization to reduce the likelihood of developing cardiac events. Methods: The multicenter, prospective cohort J-ACCESS 4 study aims to clarify the prognostic impact of reducing myocardial ischemia determined using electrocardiogram-gated MPS in Japanese patients with coronary artery disease. We started to register patients in J-ACCESS 4 at 74 facilities during June 2012 and will continue to do so until December 2013 or until the cohort comprises 500 patients who will participate in the study from one month before, until two months after stress/rest MPS assessment. Imaging data, the background of the patients including coronary risk factors and treatment before MPS assessments will be analyzed. The patients will undergo coronary revascularization within two months after MPS and/or receive appropriate medical therapy. The second stress/rest MPS will be performed from 4 to 10 months after coronary revascularization or registration. They will be followed up for over one year after the second MPS assessment. The primary endpoints will be cardiac death, sudden death of unknown cause, non-fatal myocardial infarction, and hospitalization for heart failure. The secondary endpoints will comprise death due to all causes including non-cardiac death and any cardiovascular events. This study will be completed in 2015. Here, we describe the design of the J-ACCESS 4 study.",
keywords = "Cardiovascular diseases, Coronary revascularization, Scintigraphy, Stenosis, Stress test",
author = "Mamoru Nanasato and Kenichi Nakajima and Hiroshi Fujita and Kan Zen and Shun Kosaka and Akiyoshi Hashimoto and Masao Moroi and Shigeru Fukuzawa and Taishiro Chikamori and Shigeyuki Nishimura and Akira Yamashina and Hideo Kusuoka and Atsushi Hirayama and Tsunehiko Nishimura",
year = "2014",
month = "2",
doi = "10.1016/j.jjcc.2013.07.006",
language = "English",
volume = "63",
pages = "159--164",
journal = "Journal of cardiography. Supplement",
issn = "0914-5087",
publisher = "Japanese College of Cardiology (Nippon-Sinzobyo-Gakkai)",
number = "2",

}

TY - JOUR

T1 - Rationale and design of J-ACCESS 4

T2 - Prognostic impact of reducing myocardial ischemia identified using ECG-gated myocardial perfusion SPECT in Japanese patients with coronary artery disease

AU - Nanasato, Mamoru

AU - Nakajima, Kenichi

AU - Fujita, Hiroshi

AU - Zen, Kan

AU - Kosaka, Shun

AU - Hashimoto, Akiyoshi

AU - Moroi, Masao

AU - Fukuzawa, Shigeru

AU - Chikamori, Taishiro

AU - Nishimura, Shigeyuki

AU - Yamashina, Akira

AU - Kusuoka, Hideo

AU - Hirayama, Atsushi

AU - Nishimura, Tsunehiko

PY - 2014/2

Y1 - 2014/2

N2 - Background: The findings of our recent study entitled, "Japanese Assessment of Cardiac Events and Survival Study by Quantitative Gated SPECT (J-ACCESS)" showed that myocardial perfusion single photon emission computed tomography (MPS) can detect coronary artery disease (CAD) and help to predict future cardiac events in patients with suspected or extant CAD. However, the extent of the benefit conferred by percutaneous coronary intervention (PCI) as an initial management strategy compared with optimal medical therapy remains controversial. Little evidence supports the notion that myocardial ischemia identified using MPS is an alternative target of coronary revascularization to reduce the likelihood of developing cardiac events. Methods: The multicenter, prospective cohort J-ACCESS 4 study aims to clarify the prognostic impact of reducing myocardial ischemia determined using electrocardiogram-gated MPS in Japanese patients with coronary artery disease. We started to register patients in J-ACCESS 4 at 74 facilities during June 2012 and will continue to do so until December 2013 or until the cohort comprises 500 patients who will participate in the study from one month before, until two months after stress/rest MPS assessment. Imaging data, the background of the patients including coronary risk factors and treatment before MPS assessments will be analyzed. The patients will undergo coronary revascularization within two months after MPS and/or receive appropriate medical therapy. The second stress/rest MPS will be performed from 4 to 10 months after coronary revascularization or registration. They will be followed up for over one year after the second MPS assessment. The primary endpoints will be cardiac death, sudden death of unknown cause, non-fatal myocardial infarction, and hospitalization for heart failure. The secondary endpoints will comprise death due to all causes including non-cardiac death and any cardiovascular events. This study will be completed in 2015. Here, we describe the design of the J-ACCESS 4 study.

AB - Background: The findings of our recent study entitled, "Japanese Assessment of Cardiac Events and Survival Study by Quantitative Gated SPECT (J-ACCESS)" showed that myocardial perfusion single photon emission computed tomography (MPS) can detect coronary artery disease (CAD) and help to predict future cardiac events in patients with suspected or extant CAD. However, the extent of the benefit conferred by percutaneous coronary intervention (PCI) as an initial management strategy compared with optimal medical therapy remains controversial. Little evidence supports the notion that myocardial ischemia identified using MPS is an alternative target of coronary revascularization to reduce the likelihood of developing cardiac events. Methods: The multicenter, prospective cohort J-ACCESS 4 study aims to clarify the prognostic impact of reducing myocardial ischemia determined using electrocardiogram-gated MPS in Japanese patients with coronary artery disease. We started to register patients in J-ACCESS 4 at 74 facilities during June 2012 and will continue to do so until December 2013 or until the cohort comprises 500 patients who will participate in the study from one month before, until two months after stress/rest MPS assessment. Imaging data, the background of the patients including coronary risk factors and treatment before MPS assessments will be analyzed. The patients will undergo coronary revascularization within two months after MPS and/or receive appropriate medical therapy. The second stress/rest MPS will be performed from 4 to 10 months after coronary revascularization or registration. They will be followed up for over one year after the second MPS assessment. The primary endpoints will be cardiac death, sudden death of unknown cause, non-fatal myocardial infarction, and hospitalization for heart failure. The secondary endpoints will comprise death due to all causes including non-cardiac death and any cardiovascular events. This study will be completed in 2015. Here, we describe the design of the J-ACCESS 4 study.

KW - Cardiovascular diseases

KW - Coronary revascularization

KW - Scintigraphy

KW - Stenosis

KW - Stress test

UR - http://www.scopus.com/inward/record.url?scp=84893786016&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84893786016&partnerID=8YFLogxK

U2 - 10.1016/j.jjcc.2013.07.006

DO - 10.1016/j.jjcc.2013.07.006

M3 - Article

C2 - 24012330

AN - SCOPUS:84893786016

VL - 63

SP - 159

EP - 164

JO - Journal of cardiography. Supplement

JF - Journal of cardiography. Supplement

SN - 0914-5087

IS - 2

ER -