RBC Flow Imaging and pO2 Measurement in Cerebral Microcirculation: Effect of Hemodilution on Oxygen Supply to Brain Cortical Arterioles

T. Arai, K. Tsukada, E. Sekizuka, C. Oshio, S. Terao, K. Hase, H. Minamitani

研究成果: Conference article

抜粋

Hemodilution is still one of the taken therapy in stroke due to increase in cardiac output and decrease in blood viscosity. However, it is not clear the effect of a decrease in oxygen carrying capacity on oxygen supplying to the brain. The aim of this study is to seek the effect of isovolemic hemodilution on oxygen supply. We observed RBC flow rate and oxygen tension pO2 on brain cortical arterioles by using closed cranial window, high-speed videomicroscopy and oxygen dependent quenching of phosphorescence technique. The result showed that RBC flow rate increased about four times from base line and pO2 values were kept within a arteliolar biological state (about a range from 70 to 90mmHg) until Hb was about 10g/dl, respectively. And more severe hemodilution made the both values decrease acutely. The results suggest the increase of RBC flow caused by isovolemic hemodilution keeps supplying oxygen to the brain cortex as low as Hb is 10g/dl.

元の言語English
ページ(範囲)1054-1057
ページ数4
ジャーナルAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
2
出版物ステータスPublished - 2003 12 1
イベントA New Beginning for Human Health: Proceddings of the 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society - Cancun, Mexico
継続期間: 2003 9 172003 9 21

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

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