RCAI-61, the 6′-O-methylated analog of KRN7000: its synthesis and potent bioactivity for mouse lymphocytes to produce interferon-γ in vivo

Takuya Tashiro, Ryusuke Nakagawa, Sayo Inoue, Masao Shiozaki, Hiroshi Watarai, Masaru Taniguchi, Kenji Mori

研究成果: Article査読

37 被引用数 (Scopus)

抄録

RCAI-61, the 6′-O-methylated analog of KRN7000, and six other analogs with modified 6′-position of the galactose moiety of KRN7000 were synthesized to examine their bioactivity for mouse lymphocytes. Methyl α-d-galactopyranoside was the starting material for RCAI-58, 61, 64, 83, 85, and 86, while RCAI-87 was prepared from methyl β-l-arabinopyranoside. Bioassay showed RCAI-61 to be a much more potent stimulant of mouse lymphocytes than KRN7000 and RCAI-56 to induce the production of a large amount of IFN-γ in vivo.

本文言語English
ページ(範囲)6827-6830
ページ数4
ジャーナルTetrahedron Letters
49
48
DOI
出版ステータスPublished - 2008 11 24

ASJC Scopus subject areas

  • 生化学
  • 創薬
  • 有機化学

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