Reactions of hypochlorite with catalase

Tadahiko Mashino, Irwin Fridovich

研究成果: Article査読

22 被引用数 (Scopus)

抄録

OCl-/HOCl imposed a rapid inactivation of catalase (hydrogen-peroxide: hydrogen-peroxide oxidoreductase, EC 1.11.1.6), some of which was slowly reversible upon subsequent exposure to H2O2. Ethanol accelerated this restoration of activity by H2O2. OCl- caused biphasic changes in the visible absorption spectrum of catalase, which were partially reversed by dithionite. A scheme of reactions involving axial ligation of one or two OCl- to heme iron, followed by heterolytic or homolytic cleavages of the OCl bond, is proposed to account for the behavior of the system.

本文言語English
ページ(範囲)63-69
ページ数7
ジャーナルBiochimica et Biophysica Acta (BBA)/Protein Structure and Molecular
956
1
DOI
出版ステータスPublished - 1988 8 31
外部発表はい

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology

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