Rearrangement of immunoglobulin k gene in a variant-type burkitt lymphoma cell line, kobk101, carrying a translocation between chromosomes 2 and 8

Masami Fujino, Nobuyuki Takayama, Shingo Kato, Koichi Matsuo, Toshiya Takano, Shinpei Nakazawa

研究成果: Article査読

3 被引用数 (Scopus)

抄録

The immunoglobulin k light-chain gene was rearranged in a Burkitt lymphoma cell line with the t(2;8) (p11;q24) translocation, KOBK101, showing recombination between the variable and the joining regions on one allele and an aberrant substitution of the region upstream of the J5 segment with an unknown sequence on another allele. Because DNA segments homologous to the consensus sequences of joining and switching regions of immunoglobulin genes were detected in the unknown sequence, we speculate that the system for either V-J or switching recombination in immunoglobulin genes may be involved in forming this unusual rearrangement.

本文言語English
ページ(範囲)24-27
ページ数4
ジャーナルJapanese Journal of Cancer Research GANN
77
1
出版ステータスPublished - 1986 1月 1

ASJC Scopus subject areas

  • 腫瘍学
  • 癌研究

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