Recent advances in catalytic asymmetric CC bond-forming reactions to ketimines promoted by metal-based catalysts

Naoya Kumagai, Masakatsu Shibasaki

研究成果: Article査読

51 被引用数 (Scopus)

抄録

Recent progress (post-2010) in the field of metal-catalyzed asymmetric CC bond-forming reactions using ketimines as electrophiles is reviewed. Compared with the corresponding aldimines, ketimines generally display less inherent reactivity and the two substituents on the imine carbon hamper prochiral-face-selection for enantioselective reactions. Recent advances with newly developed catalytic systems have resulted in several solutions to these long-standing problems. The construction of tetrasubstituted stereogenic centers is a crucial topic of asymmetric catalysis in the 21st century, and it is becoming increasingly clear that reactions using ketimines as electrophiles become one of the most important routes to access such chemical entities.

本文言語English
ページ(範囲)503-517
ページ数15
ジャーナルBulletin of the Chemical Society of Japan
88
4
DOI
出版ステータスPublished - 2015
外部発表はい

ASJC Scopus subject areas

  • 化学 (全般)

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