Recombinant human nerve growth factor infusions prevent cholinergic neuronal degeneration in the adult primate brain

Mark H. Tuszynski, Hoi Sang U, Kazunari Yoshida, Fred H. Gage

研究成果: Article査読

174 被引用数 (Scopus)

抄録

Atrophy of cholinergic neurons is a prominent component of Alzheimer's disease, and may explain in part the profound memory loss that is characteristic of patients with this disorder. Previous studies in animal models have shown that infusions of nerve growth factor into the adult brain can prevent both age‐related and lesion‐induced cholinergic neuronal atrophy. Recently, recombinant human nerve growth factor was found biologically active in nonprimate animal models. In the present experiment, recombinant human nerve growth factor infusions into the brains of adult primates prevented lesion‐induced cholinergic neuronal degeneration and promoted cholinergic neurite sprouting. These findings provide additional support for potential therapeutic trials of human nerve growth factor in patients with Alzheimer's disease.

本文言語English
ページ(範囲)625-636
ページ数12
ジャーナルAnnals of Neurology
30
5
DOI
出版ステータスPublished - 1991 11月
外部発表はい

ASJC Scopus subject areas

  • 神経学
  • 臨床神経学

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