Reconciling neuronally and nonneuronally derived acetylcholine in the regulation of immune function

Koichiro Kawashima, Takeshi Fujii, Yasuhiro Moriwaki, Hidemi Misawa, Kazuhide Horiguchi

研究成果: Article査読

56 被引用数 (Scopus)

抄録

Immune cells, including lymphocytes, express muscarinic and nicotinic acetylcholine (ACh) receptors (mAChRs and nAChRs, respectively), and agonist stimulation of these AChRs causes functional and biochemical changes in the cells. The origin of the ACh that acts on immune cell AChRs has remained unclear until recently, however. In 1995, we identified choline acetyltransferase mRNA and protein in human T cells, and found that immunological T cell activation potentiated lymphocytic cholinergic transmission by increasing ACh synthesis and AChR expression. We also found that M1/M5 mAChR signaling upregulates IgG1 and proinflammatory cytokine production, whereas α7 nAChR signaling has the opposite effect. These findings suggest that ACh synthesized by T cells acts as an autocrine and/or paracrine factor via AChRs on immune cells to modulate immune function. In addition, a recently discovered endogenous allosteric α7 nAChR ligand, SLURP-1, also appears to be involved in modulating normal T cell function.

本文言語English
ページ(範囲)7-17
ページ数11
ジャーナルAnnals of the New York Academy of Sciences
1261
1
DOI
出版ステータスPublished - 2012 7

ASJC Scopus subject areas

  • 神経科学(全般)
  • 生化学、遺伝学、分子生物学(全般)
  • 科学史および科学哲学

フィンガープリント

「Reconciling neuronally and nonneuronally derived acetylcholine in the regulation of immune function」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル