Recurrent bacterial pneumonia due to immunoglobulin G2 subclass deficiency after allogeneic hematopoietic stem cell transplantation: Efficacy of immunoglobulin replacement

Rie Yamazaki, Taku Kikuchi, Jun Kato, Masatoshi Sakurai, Yuya Koda, Risa Hashida, Yusuke Yamane, Ryohei Abe, Naoki Hasegawa, Shinichiro Okamoto, Takehiko Mori

研究成果: Article査読

4 被引用数 (Scopus)

抄録

Immunoglobulin (Ig) G2 subclass deficiency is known to be associated with recurrent bacterial respiratory infections caused by capsulated bacteria. We encountered a case of recurrent pneumonia due to Streptococcus pneumoniae after allogeneic hematopoietic stem cell transplantation (HSCT). IgG2 subclass level was specifically low, and prophylactic Ig replacement successfully prevented subsequent infections. However, the cessation of Ig replacement resulted in subsequent pneumonia. These findings suggested that IgG2 deficiency could be a cause of recurrent pneumococcal infection after allogeneic HSCT.

本文言語English
ジャーナルTransplant Infectious Disease
DOI
出版ステータスAccepted/In press - 2018 1 1

ASJC Scopus subject areas

  • Transplantation
  • Infectious Diseases

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