Recurrent herpes simplex virus infection in a patient with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy associated with L29P and IVS9-1G>C compound heterozygous autoimmune regulator gene mutations

S. Nagafuchi, K. Umene, F. Yamanaka, S. Oohashi, M. Shindo, H. Kurisaki, J. Kudoh, N. Shimizu, T. Hara, M. Harada

研究成果: Article査読

11 被引用数 (Scopus)

抄録

Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) has characteristic clinical features with organ-specific autoimmune polyendocrine diseases and candidiasis, caused by the mutations of autoimmune regulator (AIRE) gene. Although almost all patients are complicated with mucocutaneous candidiasis, no apparent susceptibility to other infections has yet been reported. We herein report that a patient with APECED suffered from recurrent herpes simplex virus type 1 (HSV-1) infection after severe primary herpetic stomatitis, associated with sequential HSV-1 isolates of the same genomic profile, consistent with endogeneous recurrence. Thus, not only candidiasis but also HSV infection should receive more attention in patients with APECED, with treatment being administered accordingly.

本文言語English
ページ(範囲)605-610
ページ数6
ジャーナルJournal of Internal Medicine
261
6
DOI
出版ステータスPublished - 2007 6

ASJC Scopus subject areas

  • 内科学

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「Recurrent herpes simplex virus infection in a patient with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy associated with L29P and IVS9-1G>C compound heterozygous autoimmune regulator gene mutations」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

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