Reduced expression of manganese superoxide dismutase mRNA may correlate with invasiveness in esophageal carcinoma

Yasushi Toh, Shinji Kuninaka, Masaki Mori, Tatsuro Oshiro, Yasuharu Ikeda, Hideaki Nakashima, Hideo Baba, Shunji Kohnoe, Takeshi Okamura, Keizo Sugimachi

研究成果: Article査読

16 被引用数 (Scopus)


Little is known about the expression and antioxidant function of manganese superoxide dismutase (Mn-SOD) in esophageal squamous cell carcinoma. To determine the significance of Mn-SOD in esophageal squamous cell carcinomas, Mn-SOD mRNA expression was examined in 45 esophageal squamous cell carcinomas and the corresponding normal mucosal tissues by reverse transcription-polymerase chain reaction. The tumor/normal (T/N) ratio of 45 patients with esophageal carcinoma was calculated, and the data were clinicopathologically analyzed. The T/N ratio of Mn-SOD mRNA expression was less than 0.5 in 11 (32.4%) of 34 esophageal carcinoma cases without any preoperative treatments, while none of 11 cases who underwent preoperative chemotherapy showed a T/N ratio of <0.5 (p < 0.05). There was an inverse correlation between the Mn-SOD expression level and the degree of venous invasion (p < 0.05) as well as lymphatic invasion (p < 0.05). Furthermore, poorly differentiated squamous cell carcinoma showed significantly lower Mn-SOD mRNA expression levels than well differentiated carcinoma (p < 0.05). Our results suggest that Mn-SOD mRNA was frequently reduced in esophageal carcinoma when compared to the normal mucosa and the reduced expression levels of Mn-SOD mRNA may lead to an accumulation of superoxide radicals in conjunction with the increased invasiveness of esophageal carcinoma. Copyright (C) 2000 S. Karger AG, Basel.

出版ステータスPublished - 2000 1月 1

ASJC Scopus subject areas

  • 腫瘍学
  • 癌研究


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