Reduced expression of TCR zeta is involved in the abnormal production of cytokines by peripheral T cells of patients with systemic lupus erythematosus

Keiko Yoshimoto, Yumiko Setoyama, Kensei Tsuzaka, Tohru Abe, Tsutomu Takeuchi

研究成果: Article査読

10 被引用数 (Scopus)

抄録

Accumulating evidence suggests that dysfunction of T cells underlies the pathogenesis of systemic lupus erythematosus (SLE). We revealed that SLE T cells produced an abnormally excessive amount of IFN- in vitro upon stimulation through TCR, and the expression level of TCR zeta was significantly reduced. The production of IFN- by SLE T cells was negatively correlated with the expression level of TCR zeta. This correlation was abolished when the cells were stimulated with TPA and ionomycin, which bypass TCR and introduce signals directly into the cells, but the production of IFN- by SLE T cells remained abnormally elevated. Taken together, these data suggest that regulatory mechanisms not only for the expression of TCR zeta but also for the production of IFN- were impaired in SLE T cells. These impairments may be responsible for the aberrant responses of SLE T cells and partly involved in the development of SLE.

本文言語English
論文番号509021
ジャーナルJournal of Biomedicine and Biotechnology
2010
DOI
出版ステータスPublished - 2010

ASJC Scopus subject areas

  • バイオテクノロジー
  • 分子医療
  • 分子生物学
  • 遺伝学
  • 健康、毒物学および変異誘発

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