TY - JOUR
T1 - Reduced levels of MMP-2 and TIMP-1 in dyssegmental dysplasia
AU - Uchide, Kiyoshi
AU - Ueno, Hirohisa
AU - Takizawa, Noboru
AU - Okada, Yasunori
PY - 2003/2/1
Y1 - 2003/2/1
N2 - Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) were measured in a mild case of dyssegmental dysplasia. X-ray pictures of a female baby born vaginally at 39 weeks of gestation showed short, bent, dumbbell-shaped long bones of the limbs and profound dyssegmental ossification in the spine, findings characteristic of dyssegmental dysplasia. When the levels of MMP-1, MMP-2, MMP-9, TIMP-1, and TIMP-2 were measured, the levels of MMP-2 and TIMP-1 were significantly reduced. This case might provide a clue to disclose the etiology of dyssegmental dysplasia.
AB - Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) were measured in a mild case of dyssegmental dysplasia. X-ray pictures of a female baby born vaginally at 39 weeks of gestation showed short, bent, dumbbell-shaped long bones of the limbs and profound dyssegmental ossification in the spine, findings characteristic of dyssegmental dysplasia. When the levels of MMP-1, MMP-2, MMP-9, TIMP-1, and TIMP-2 were measured, the levels of MMP-2 and TIMP-1 were significantly reduced. This case might provide a clue to disclose the etiology of dyssegmental dysplasia.
KW - Bone
KW - Congenital anomaly
KW - Dyssegmental dysplasia
KW - Matrix metalloproteinases
KW - Tissue inhibitors of metalloproteinases
UR - http://www.scopus.com/inward/record.url?scp=0037302859&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037302859&partnerID=8YFLogxK
U2 - 10.1359/jbmr.2003.18.2.381
DO - 10.1359/jbmr.2003.18.2.381
M3 - Article
C2 - 12568417
AN - SCOPUS:0037302859
VL - 18
SP - 381
EP - 382
JO - Journal of Bone and Mineral Research
JF - Journal of Bone and Mineral Research
SN - 0884-0431
IS - 2
ER -
