Reduced p27(Kip1) expression in hepatocellular carcinomas

Ai Min Hui, Lin Sun, Yae Kanai, Michiie Sakamoto, Setsuo Hirohashi

研究成果: Article査読

32 被引用数 (Scopus)

抄録

This study was designed to determine whether changes in p27(Kip1) expression are involved in human hepatocarcinogenesis. We examined the p27(Kip1) mRNA expression in hepatocellular carcinomas and surrounding non-cancerous liver tissue samples from 21 patients using a reverse-transcriptase polymerase chain reaction assay. The mean p27(Kip1) mRNA expression levels (ratio of p27(Kip1)/β-actin mRNA) were significantly lower in hepatocellular carcinomas than in non-cancerous liver tissues (0.49±0.24 versus 0.57±0.22, P<0.05). p27(Kip1) mRNA expression was reduced in 11 (52%) of the 21 hepatocellular carcinomas when compared with the surrounding non-cancerous liver tissues. These findings suggest that reduced p27(Kip1) expression may be at least partly responsible for human hepatocarcinogenesis. Copyright (C) 1998 Elsevier Science Ireland Ltd.

本文言語English
ページ(範囲)67-73
ページ数7
ジャーナルCancer Letters
132
1-2
DOI
出版ステータスPublished - 1998 10 23
外部発表はい

ASJC Scopus subject areas

  • 腫瘍学
  • 癌研究

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