Reference values for salivary cortisol in healthy young infants by liquid chromatography–tandem mass spectrometry

Mayako Saito-Abe, Kiwako Yamamoto-Hanada, Shoji F. Nakayama, Yuki Hashimoto, Osamu Natsume, Maki Fukami, Tomonobu Hasegawa, Yukihiro Ohya

研究成果: Article査読

抄録

Background: Sampling of salivary cortisol is non-invasive and important for the evaluation of the hypothalamic–pituitary–adrenal axis function and stress levels. However, the reference values for salivary cortisol measured by liquid chromatography–tandem mass spectrometry (LC-MS/MS) in healthy infants are unclear. The aim of this study was to establish the reference values for salivary cortisol levels in healthy infants. Methods: This study was a prospective observational cohort study following the participants until the age of 6 months. We analyzed 71 healthy, full-term infants at age 1 month between December 2017 and March 2018. We repeated saliva sampling every month, measured the salivary cortisol levels in the early morning by LC-MS/MS, and took the subjects’ medical history by questionnaire. Results: The minimum, 25th, 50th, 75th percentile, and maximum salivary cortisol levels were 0.08, 1.11, 2.21, 5.18, and 30.35 nmol/L, respectively. Conclusions: We established the reference values for salivary cortisol in young infants using LC-MS/MS.

本文言語English
ページ(範囲)785-788
ページ数4
ジャーナルPediatrics International
62
7
DOI
出版ステータスPublished - 2020 7 1

ASJC Scopus subject areas

  • 小児科学、周産期医学および子どもの健康

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