Regeneration of the central nervous system using endogenous repair mechanisms

Hideyuki Okano, Masanori Sakaguchi, Koichi Ohki, Norihiro Suzuki, Kazunobu Sawamoto

研究成果: Review article査読

95 被引用数 (Scopus)


Recent advances in developmental and stem cell biology have made regeneration-based therapies feasible as therapeutic strategies for patients with damaged central nervous systems (CNSs), including those with spinal cord injuries, Parkinson disease, or stroke. These strategies can be classified into two approaches: (i) the replenishment of lost neural cells and (ii) the induction of axonal regeneration. The first approach includes the activation of endogenous neural stem cells (NSCs) in the adult CNS and cell transplantation therapy. Endogenous NSCs have been shown to give rise to new neurons after insults, including ischemia, have been sustained; this form of neurogenesis followed by the migration and functional maturation of neuronal cells, as well as the responses of glial cells and the vascular system play crucial roles in endogenous repair mechanisms in damaged CNS tissue. In this review, we will summarize the recent advances in regeneration-based therapeutic approaches using endogenous NSCs, including the results of our own collaborative groups.

ジャーナルJournal of Neurochemistry
出版ステータスPublished - 2007 9月

ASJC Scopus subject areas

  • 生化学
  • 細胞および分子神経科学


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