Regenerative medicine for spinal cord injury utilizing iPS cells

Osahiko Tsuji, Satoshi Nori, Yoshiomi Kobayashi, Kanehiro Fujiyoshi, Hideyuki Okano, Yoshiaki Toyama, Masaya Nakamura

研究成果: Chapter

抄録

Reports of functional recovery from spinal cord injury (SCI) after the transplantation of rat-fetus-derived neural stem/precursor cells (NS/PCs) and murine embryonic stem cells (ES cells) have raised great expectations for the successful clinical trial of stem cell transplantation therapy. However, the ethical issues concerning about destroying human embryos or fertilized oocytes to obtain such stem cells have been a major impediment to developing clinically useful stem cell sources and to use them in clinical applications. Recently, induced pluripotent stem cells (iPS cells), which can serve as a source of autologous cell transplantation, have been attracting a lot of attention as a clinically practical alternative to stem cells obtained directly from tissues. In this chapter, we outline the neural induction of murine and human iPS cells, their therapeutic efficacy in mouse and primate SCI models, and their safety in vivo.

本文言語English
ホスト出版物のタイトルNeuroprotection and Regeneration of the Spinal Cord
出版社Springer Japan
ページ229-245
ページ数17
9784431545026
ISBN(電子版)9784431545026
ISBN(印刷版)4431545018, 9784431545019
DOI
出版ステータスPublished - 2014 11 1

ASJC Scopus subject areas

  • Medicine(all)

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